Prostate motion during online adaptation supports routine verification before treatment
Across 1,378 adaptive fractions, 4.6% had shifts above 6 mm and longer adaptation times were linked to greater prostate displacement.
Tag
online-adaptive
RTT-led online adaptive radiotherapy maintained cervical target coverage in 33-minute sessions
Across 744 cervical oART fractions, RTT-led adaptation took a median 33 minutes while maintaining ≥95% target D98 in every fraction.
Daily online adaptation reduced acute GI toxicity during hypofractionated prostate radiotherapy
Grade ≥2 GI toxicity was 14% with oART versus 45% with IGRT, with better preservation of several HRQoL domains.
Online adaptive proton SBRT was feasible in the phase I PARTY trial
All 50 proton SBRT fractions were completed, with online adaptation used in 84% to restore target coverage or resolve OAR violations.
Online adaptive MRgRT time fell from 67 to 48 minutes over eight years
Median online adaptive MR-guided treatment time fell 28% despite increasing complexity, with 78% of late-era fractions completed within 60 minutes.
CBCT-guided online adaptation consistently improved dosimetry, but clinical evidence remains limited
Across 127 studies, CBCT-guided online adaptation repeatedly improved target coverage and OAR sparing, while evidence for better clinical outcomes remained sparse.
Prostate target expansion identified fractions most likely to benefit from online re-optimization
Without online re-optimization, 65.3% of prostate fractions missed 95% target coverage, with later target expansion strongly linked to coverage loss.
On Ethos, intensity-modulated radiotherapy generated faster and spared several pelvic organs better than arc therapy
Nine-field intensity-modulated radiotherapy shortened overall planning-plus-delivery time and improved several pelvic dose metrics compared with volumetric modulated arc therapy.
Daily adaptation supported 17-fraction definitive chemoradiotherapy for cervical cancer
Daily online adaptation improved pelvic target coverage during 17-fraction cervical chemoradiotherapy, with 10% grade ≥3 gastrointestinal toxicity.
Simulation-free CBCT workflow enabled urgent radiotherapy within about two hours
The OSCAR workflow delivered the first urgent or palliative fraction without planning CT in approximately 1 hour 50 minutes.
Simulation-free adaptive lung SBRT was feasible in the ONE STOP pilot
Eight of ten patients completed simulation-free single-fraction adaptive lung SBRT, with treatment taking a median 72 minutes.
Online proton adaptation improved dosimetry but required about one hour per fraction
Adaptation would have improved organ sparing or target coverage in 46% of fractions, with a median workflow time of 61.9 minutes.
Daily adaptation improved target coverage and rectal sparing in postoperative prostate radiotherapy
Daily adaptation increased prostate-bed coverage from 92.1% to 98.5% and reduced high-dose rectal exposure during hypofractionated salvage radiotherapy.
CT-guided online adaptation improved prostate SBRT dosimetry
CT-guided online adaptive prostate SBRT was feasible, with adapted plans selected in 95% of fractions and dosimetric improvements in 85%.
Rectal air did not compromise prostate online adaptive radiotherapy robustness
Rectal air or air-filled balloons did not cause clinically relevant dose increases when posterior tissue shifts stayed within 5 millimetres.