NanOx incompletely predicted laryngeal cancer cell survival across a helium Bragg peak
NanOx predictions differed from measured laryngeal cancer cell survival by 20–37% and overestimated the distal biological gradient.
Tag
particle-therapy
Helium pencil beam commissioning achieved submillimetre range accuracy and robust dose agreement
A scanned helium beamline achieved submillimetre range accuracy and generally ≤3% dose agreement, supporting further translation toward clinical helium therapy.
In-beam PET enabled real-time radioactive ion beam range adaptation in mice
Radioactive carbon-11 beams enabled PET-guided range adjustment during irradiation, with biological outcomes matching insufficient, optimal and excessive beam penetration.
Review proposes harmonized reporting of biological dose across particle therapies
A translational review proposes shared reporting and quality-assurance principles for model-dependent biological dose in proton, carbon-ion and boron neutron capture therapy.
Particle therapy costing studies show major methodological heterogeneity
Only 12 eligible studies were found, with inconsistent methods and assumptions that limited meaningful comparison of particle therapy costs.
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.