EPTN marks a decade of European particle therapy collaboration and sets its next priorities
After 10 years, EPTN is shifting its focus toward prospective registries, adaptive therapy, harmonised QA and stronger clinical evidence.
Tag
particle-therapy
Ultra-low-field MRI operated during particle delivery without relevant dosimetric disruption
A portable 49 mT MRI system operated during proton and carbon-ion delivery with stable imaging and minimal dosimetric impact.
Experts define the roadmap for clinical upright gantry-less radiotherapy
Upright gantry-less RT could reduce system complexity and improve access, but imaging, immobilization and limited clinical evidence remain major barriers.
Modern radiotherapy shifted the accuracy problem from dose calibration to spatial dose delivery
Modern dosimetry can meet historical accuracy requirements, but tighter geometric precision and particle-specific uncertainties increasingly determine treatment accuracy.
Particle therapy suppressed aggressive breast cancer behavior beyond clonogenic cell killing
Protons, helium and carbon ions suppressed migration and invasion that increased after photon irradiation, with helium showing a favorable biological-dosimetric balance.
PTCOG review maps emerging roles for particle therapy in gynecologic cancers
Carbon ions show the strongest signal in radioresistant gynecologic tumors, while proton evidence centers on adjuvant treatment and reirradiation.
AI is moving across particle therapy planning but clinical validation remains the bottleneck
AI can automate particle planning, dose prediction, adaptation and quality assurance, but limited data and validation still constrain clinical adoption.
NanOx incompletely predicted laryngeal cancer cell survival across a helium Bragg peak
NanOx predictions differed from measured laryngeal cancer cell survival by 20–37% and overestimated the distal biological gradient.
Helium pencil beam commissioning achieved submillimetre range accuracy and robust dose agreement
A scanned helium beamline achieved submillimetre range accuracy and generally ≤3% dose agreement, supporting further translation toward clinical helium therapy.
In-beam PET enabled real-time radioactive ion beam range adaptation in mice
Radioactive carbon-11 beams enabled PET-guided range adjustment during irradiation, with biological outcomes matching insufficient, optimal and excessive beam penetration.
Review proposes harmonized reporting of biological dose across particle therapies
A translational review proposes shared reporting and quality-assurance principles for model-dependent biological dose in proton, carbon-ion and boron neutron capture therapy.
Particle therapy costing studies show major methodological heterogeneity
Only 12 eligible studies were found, with inconsistent methods and assumptions that limited meaningful comparison of particle therapy costs.
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.