Glioblastoma target volumes change substantially during MR-guided radiotherapy, often within the first week
Serial MR-linac imaging showed frequent glioblastoma target changes, with some extending beyond the planned CTV and 95% isodose.
Tag
preliminary
Six-fraction RT produced rapid symptom relief in tumors involving the brachial plexus
A 33 Gy/6-fraction boost regimen improved plexus-related symptoms in 84% of evaluable patients and achieved 74% freedom from local progression at one year.
DW-MRI-guided parotid sparing showed exploratory acute toxicity and quality-of-life signals
Lower dose to diffusion-defined contralateral parotid subvolumes showed early associations with xerostomia-related outcomes, but most dose–toxicity relationships were not significant.
MRI-derived oxygen extraction fell progressively during prostate MR-guided SBRT
Relative oxygen extraction declined across irradiated prostate and tumor tissue during five-fraction MRgSBRT, with the largest early changes.
Carbon-ion radiotherapy achieved 91% two-year local control in limited-stage SCLC
In 39 patients, carbon-ion RT achieved 91.2% two-year local control without grade ≥3 acute radiation-associated toxicity.
Salvage HDR brachytherapy delayed systemic therapy after isolated seminal vesicle recurrence
In 22 patients, salvage HDR brachytherapy produced 40.5% five-year relapse-free survival but 18% developed grade ≥3 GU toxicity.
PACIFIC-style CRT offers a curative fallback when resectable NSCLC becomes unresectable during neoadjuvant therapy
In MDT-BRIDGE, patients who became unresectable during neoadjuvant durvalumab plus chemotherapy could transition to definitive CRT and consolidation durvalumab, with 85% 12-month PFS in a small selected cohort.
Liposomal irinotecan plus capecitabine TNT achieves 21.7% complete response in locally advanced rectal cancer
In phase II LipCap, liposomal irinotecan plus capecitabine with long-course chemoradiotherapy produced a 21.7% overall complete response rate in LARC, with grade 3-4 toxicity in 16.7%. Long-term efficacy remains unknown.
PTSD symptom burden affected 29% after cervical cancer HDR brachytherapy
Nearly three in ten surveyed cervical cancer survivors reported partial-to-probable PTSD symptoms several years after HDR brachytherapy.
Five-fraction SBRT showed encouraging early safety in frail stage III NSCLC
Sequential chemotherapy plus five-fraction SBRT produced 86.7% one-year local control with 7.7% acute grade 3 toxicity in STARLORD.
MRI improved LLM-based recurrence prediction after definitive cervical chemoradiotherapy
Multimodal LLM prediction reached an AUC of 0.79, but AI-generated MRI reports showed clinically important discordances requiring expert review.
Four support needs may help children complete proton therapy without anaesthesia
Control, predictability, information and relational continuity emerged as key needs for making awake pediatric proton therapy more manageable.
CTCAE v6.0 grading varied across identical gynecologic radiotherapy toxicity cases
In a small ESTRO poll, subjective and lower-grade adverse events showed substantial disagreement despite shared CTCAE v6.0 definitions.
Cognitive engagement prolonged deep-inspiration breath-hold during breast radiotherapy
A simple counting task added about 19 seconds to prolonged DIBH in breast cancer patients after oxygenation and hyperventilation.
CT lung-density changes may identify patient-specific radiosensitivity before thoracic re-irradiation
Normal-lung CT response was partly reproducible across RT courses, while short retreatment intervals increased response in previously irradiated lung.