HyperArc delivered stereotactic re-irradiation to 44 brain metastases after prior whole-brain RT
One patient underwent 21 Gy in three fractions to 44 recurrent brain metastases after WBRT, with rapid delivery and sustained local control.
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preliminary
High-dose exposure to the IAS–puborectalis complex tracked with LARS after rectal radiotherapy
Postoperative bowel dysfunction correlated most strongly with high-dose exposure to the internal anal sphincter and puborectalis complex.
High-dose prednisone produced transient symptom improvement in radiation-associated lower cranial neuropathy
Prednisone 3 mg/kg improved symptoms in 3 of 5 survivors with late cranial neuropathy, but the benefit disappeared by 6–10 weeks.
Upfront 54 Gy radiotherapy stopped growth of an inoperable cranial Masson’s tumor
In one rapidly enlarging cranial Masson’s tumor, 54 Gy in 27 fractions halted growth and enabled subsequent necrosectomy.
Focal lumbosacral plexus hotspots may contribute to severe toxicity after prostate radiotherapy
Two prostate RT cases suggest that focal lumbosacral plexus hotspots, particularly near 70 Gy, may contribute to severe neurologic toxicity.
Endorectal balloon enabled 78 Gy salvage boost for prostate-bed recurrence
In one macroscopic recurrence abutting rectum, an endorectal balloon reduced rectal V75 from 24.6% to 8.6%, enabling a 78 Gy boost.
TIMELESS–SIRT1–Ku70 signaling promoted NHEJ-mediated radioresistance in cervical cancer models
TIMELESS scaffolded SIRT1-mediated Ku70 deacetylation, enhanced NHEJ repair and increased radioresistance in cervical cancer cells and xenografts.
Carbon-ion radiotherapy showed feasibility for unresectable radiation-induced sarcoma
In eight previously irradiated patients, CIRT achieved 71% one-year local control and 75% survival, with grade ≥3 toxicity in 25%.
Autophagy inhibition radiosensitized IDH1-mutant glioma in preclinical models
ATG7 inhibition plus radiation doubled median survival versus untreated mice and produced long-term tumor-free survival in 40%.
Flap-sparing postoperative RT showed no intraflap recurrences in oral cavity cancer
Among 34 postoperative oral cavity cases, local failures occurred at or near the flap-native interface, with no recurrence inside the flap.
Postoperative high-dose RT achieved strong local control in lacrimal gland adenoid cystic carcinoma
After surgery plus 66–70 Gy, only one of six patients recurred locally, while half developed distant metastases.
Two-week PACTUS radiotherapy showed feasibility in frail patients with anal cancer
PACTUS 40 Gy/10 produced 30-month median survival in 28 selected frail patients, but incomplete response and toxicity data limit efficacy conclusions.
Extensive keloids had high wound dehiscence after postoperative radiotherapy
Wound dehiscence occurred in 78% of extensively involved keloid sites versus 5% of simple lesions after surgery and postoperative RT.
Endorectal HDR brachytherapy produced 80% initial response in frail rectal cancer
Short-course EBRT plus endorectal HDR brachytherapy produced 80% cCR/ncCR, but grade 3 late rectal toxicity occurred in 27%.
Chemotherapy-free RT plus durvalumab was feasible in PD-L1-high locally advanced NSCLC
Concurrent durvalumab with either 60 Gy/15 or 60 Gy/30 was feasible in a 24-patient phase I study without concurrent chemotherapy.