Perirenal hydrogel spacer reduced bowel dose in simulated kidney SBRT
In one cadaveric RCC plan, stable 1-cm perirenal separation reduced large-bowel Dmax from 34.5 to 22.1 Gy.
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preliminary
VMAT with a custom 3D bolus treated nasal BCC with low early toxicity
Seven patients completed 60 Gy with no recurrences, grade ≥3 skin toxicity, fibrosis, cartilage necrosis, or nasal contour deformation at early follow-up.
Postoperative VMAT was feasible after aortic-allograft tracheal reconstruction for adenoid cystic carcinoma
Four patients completed 54 Gy after airway reconstruction without graft-related toxicity or local recurrence during early follow-up.
Hemorrhagic colitis developed during proton therapy after intensive neuroblastoma treatment
A child developed hemorrhagic colitis after only 12.6 Gy(RBE), suggesting preceding intensive systemic therapy may increase bowel vulnerability.
Online adaptive proton SBRT was feasible in the phase I PARTY trial
All 50 proton SBRT fractions were completed, with online adaptation used in 84% to restore target coverage or resolve OAR violations.
Memory-network avoidance PCI was feasible beyond hippocampal sparing in limited-stage SCLC
VMAT-based PCI spared additional memory-network structures while maintaining whole-brain coverage in two patients with limited-stage SCLC.
Tumor-spread modeling enabled anisotropic glioblastoma treatment planning beyond MRI-visible disease
Model-predicted microscopic glioblastoma spread could be incorporated into clinically deliverable plans, but dose-painting accuracy deteriorated as target complexity increased.
Stereotactic boost after recent radiotherapy achieved 86.5% one-year local control
A phase I study safely escalated five-fraction stereotactic boosts to 30-35 Gy after recent prior radiotherapy, with 86.5% one-year local control.
MRI radiomics did not robustly outperform clinical predictors after head and neck chemoradiotherapy
A best MRI model reached AUC 0.91, but across 366 configurations radiomics did not consistently outperform a simple clinical model.
Salvage proton therapy achieved durable control after prostate cryotherapy or HIFU failure
Ten-year biochemical control was 64.7% after salvage proton therapy, with 3.2% late grade 3 genitourinary toxicity.
Benzydamine spray reduced severe mucositis in a randomized head and neck pilot
Grade ≥3 mucositis at week 6 occurred in 11.1% with benzydamine versus 70.6% with standard care.
Dose accumulation was feasible for toxicity assessment in MR-guided abdominal SABR
Accumulated gastrointestinal doses were generally lower than planned, while higher small-bowel dose showed exploratory associations with diarrhoea after MR-guided SABR.
MRI radiomics moderately predicted VEGFA expression in lower-grade glioma
MRI radiomics predicted VEGFA expression with validation AUC 0.718, while high VEGFA independently correlated with worse overall survival.
NRF2-WNT5A signaling promoted stemness and radioresistance in esophageal squamous cancer
NRF2 directly activated WNT5A, sustaining β-catenin signaling, cancer stemness and radioresistance across esophageal cancer models.
Reduced-volume MR-guided RT was feasible in glottic cancer, with two recurrences
Reduced-volume MR-guided RT caused no grade ≥3 toxicity, but two of ten patients developed in-field recurrence after five-fraction treatment.