Three-cycle thoracic Quad Shot was feasible with concurrent systemic therapy in metastatic NSCLC
Three Quad Shot cycles caused limited high-grade toxicity, no systemic-therapy delays and frequent thoracic symptom improvement.
Tag
preliminary
Carbon ions produced more persistent tumor damage but hypoxic cells showed late rebound
Carbon ions prolonged tumor-cell damage while chronic hypoxia supported late proliferative and macrophage rebound in rat prostate tumors.
Severe pneumonitis developed after carbon-ion RT following nivolumab in lung cancer
Life-threatening bilateral pneumonitis with concurrent Pneumocystis infection developed three days after carbon-ion RT in a patient previously treated with nivolumab.
Particle therapy suppressed aggressive breast cancer behavior beyond clonogenic cell killing
Protons, helium and carbon ions suppressed migration and invasion that increased after photon irradiation, with helium showing a favorable biological-dosimetric balance.
FES PET changed nodal staging, field design and boost dose in ER-positive breast cancer
In a diagnostically difficult breast cancer case, FES PET identified occult ER-positive nodal disease and materially changed radiotherapy volume and dose.
Submandibular gland transfer reduced salivary-gland dose by 12 Gy during proton therapy
Surgical transfer reduced contralateral submandibular mean dose by approximately 12 Gy during bilateral IMPT without compromising target coverage.
DNA-PK and ATM inhibition strongly radiosensitized uveal melanoma models to proton therapy
Blocking DNA double-strand-break repair enhanced proton response across seven uveal melanoma spheroid models, with DNA-PK inhibition showing the strongest effect.
3D-printed oral stents were associated with less toxicity after nasopharyngeal radiotherapy
Patient-specific stents improved tongue and parotid stability and were associated with substantially less hearing loss, dysphagia and dysgeusia.
Metformin reshaped glioblastoma immunity and improved radiotherapy response in mice
Metformin plus radiotherapy prolonged survival in two syngeneic glioblastoma models while shifting macrophage and T-cell populations toward antitumor phenotypes.
S100A8/A9 blockade improved survival after abdominal irradiation in mice
Paquinimod blockade of S100A8/A9 improved survival, intestinal regeneration and barrier recovery after abdominal irradiation in preclinical models.
Minibeam radiotherapy achieved 92% one-year local control in refractory superficial tumors
In the first clinical minibeam series, 86% had symptomatic improvement and one-year local control reached 92% with minibeam treatment alone.
DWI/ADC changed residual cervical tumor geometry before brachytherapy despite similar overall volumes
Adding DWI/ADC produced substantially different residual GTV geometry before cervical brachytherapy, with a median Dice overlap of only 0.33.
Dose–LET hotspots were associated with capsular contracture after proton postmastectomy radiotherapy
Combined high-dose and high-LET exposure around breast implants was associated with severe capsular contracture after proton postmastectomy radiotherapy.
Multi-RBE LET optimization increased target LET by 29% in sacral chordoma
Multi-RBE carbon-ion optimization increased near-minimum GTV LET by 29.2% while maintaining conventional dose coverage and interfraction robustness.
Decision aid supported DAHANCA 35 trial discussions when clinicians actively used it
A DAHANCA 35 patient decision aid was feasible and acceptable, but its value depended strongly on clinician introduction and engagement.