Fat saturation destabilized most MRI radiomics features used for radionecrosis prediction
Only 10.7% of T2 MRI radiomics features remained highly stable across fat-saturation protocols, and stability filtering improved prediction.
Tag
Protons
Submandibular gland transfer reduced salivary-gland dose by 12 Gy during proton therapy
Surgical transfer reduced contralateral submandibular mean dose by approximately 12 Gy during bilateral IMPT without compromising target coverage.
LET-optimized proton arc planning more than doubled the lattice peak-to-valley dose ratio
PATLESL increased lattice peak-to-valley dose ratio from 16.9 to 41.9 while reducing spot number and delivery time.
Beam-deflection compensation restored proton dose delivery inside an in-beam MR scanner
Energy-layer-wise compensation restored millimetre-level proton targeting despite magnetic-field beam shifts approaching 30 mm in an MR-integrated prototype.
DNA-PK and ATM inhibition strongly radiosensitized uveal melanoma models to proton therapy
Blocking DNA double-strand-break repair enhanced proton response across seven uveal melanoma spheroid models, with DNA-PK inhibition showing the strongest effect.
Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.
Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
OPT-former enabled near-real-time automated eye tracking during ocular proton therapy
OPT-former matched a three-network segmentation pipeline while processing eye images 2.6 times faster and improved further with patient-specific fine-tuning.
Dose–LET hotspots were associated with capsular contracture after proton postmastectomy radiotherapy
Combined high-dose and high-LET exposure around breast implants was associated with severe capsular contracture after proton postmastectomy radiotherapy.
Decision aid supported DAHANCA 35 trial discussions when clinicians actively used it
A DAHANCA 35 patient decision aid was feasible and acceptable, but its value depended strongly on clinician introduction and engagement.
Reusable 3D-printed devices shaped small proton fields for under $1 in filament
Hollow 3D-printed proton collimators and compensators were produced within 45 minutes and accurately shaped small experimental proton fields.
Automated proton planning reproduced clinical head and neck NTCP estimates within minutes
Automated proton plans reproduced clinical dysphagia and xerostomia estimates closely while reducing optimization time from days to about one hour.
Ultra-high dose-rate proton DNA damage changed with scavenger concentration and dose
Ultra-high dose-rate protons produced fewer DNA breaks at low scavenger concentration, but the effect diminished or reversed under other experimental conditions.
Local control was similar across proton, photon and stereotactic radiotherapy for grade 1 meningioma
Five-year local control exceeded 89% across proton, photon and stereotactic approaches, with no significant modality effect in meta-regression.
Heart dose rises during esophageal IMPT but adaptive replanning limits the increase
Mean heart dose increased during esophageal IMPT, while heart-dose–triggered replanning reduced the excess dose in patients requiring adaptation.