Proton hemithoracic irradiation achieved major normal-tissue sparing with limited severe pneumonitis
Proton IMPRINT kept contralateral lung mean dose at 0.3 Gy, with grade 3 pneumonitis occurring in 6% of patients.
Tag
Protons
Proton hypofractionation achieved durable control in heavily reirradiated spine metastases
Proton hypofractionation produced 10% one-year local failure despite extensive prior irradiation, with grade 3 toxicity confined to multiply reirradiated patients.
Severe brainstem necrosis followed standard proton CSI in 22q11.2 deletion syndrome
A patient with 22q11.2 deletion developed refractory brainstem necrosis nine months after guideline-concordant proton craniospinal irradiation.
Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.
Modern proton breast radiotherapy offers cardiopulmonary sparing but randomized clinical benefit remains pending
Modern proton techniques reduce cardiopulmonary dose and can control skin exposure, while randomized cardiac and cancer-control endpoints remain pending.
Antiscatter grid sharply improved proton CBCT accuracy and soft-tissue contrast
A 2D antiscatter grid reduced soft-tissue CT-number error from 169 to 38 HU at unchanged imaging dose.
Daily skin variation caused substantial target underdose in kidney proton SABR
Daily surface changes shifted proton beam depth by up to 17.4 mm and reduced accumulated target D99 by up to 24.3%.
Breathing-phase targeting reduced normal-tissue dose in proton lung radiotherapy
Planning on selected respiratory phases reduced lung, heart and esophageal dose, but the optimal phase differed by toxicity endpoint.
Fat saturation destabilized most MRI radiomics features used for radionecrosis prediction
Only 10.7% of T2 MRI radiomics features remained highly stable across fat-saturation protocols, and stability filtering improved prediction.
Submandibular gland transfer reduced salivary-gland dose by 12 Gy during proton therapy
Surgical transfer reduced contralateral submandibular mean dose by approximately 12 Gy during bilateral IMPT without compromising target coverage.
LET-optimized proton arc planning more than doubled the lattice peak-to-valley dose ratio
PATLESL increased lattice peak-to-valley dose ratio from 16.9 to 41.9 while reducing spot number and delivery time.
Beam-deflection compensation restored proton dose delivery inside an in-beam MR scanner
Energy-layer-wise compensation restored millimetre-level proton targeting despite magnetic-field beam shifts approaching 30 mm in an MR-integrated prototype.
DNA-PK and ATM inhibition strongly radiosensitized uveal melanoma models to proton therapy
Blocking DNA double-strand-break repair enhanced proton response across seven uveal melanoma spheroid models, with DNA-PK inhibition showing the strongest effect.
Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.
Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.