OPT-former enabled near-real-time automated eye tracking during ocular proton therapy
OPT-former matched a three-network segmentation pipeline while processing eye images 2.6 times faster and improved further with patient-specific fine-tuning.
Tag
Protons
Dose–LET hotspots were associated with capsular contracture after proton postmastectomy radiotherapy
Combined high-dose and high-LET exposure around breast implants was associated with severe capsular contracture after proton postmastectomy radiotherapy.
Decision aid supported DAHANCA 35 trial discussions when clinicians actively used it
A DAHANCA 35 patient decision aid was feasible and acceptable, but its value depended strongly on clinician introduction and engagement.
Reusable 3D-printed devices shaped small proton fields for under $1 in filament
Hollow 3D-printed proton collimators and compensators were produced within 45 minutes and accurately shaped small experimental proton fields.
Automated proton planning reproduced clinical head and neck NTCP estimates within minutes
Automated proton plans reproduced clinical dysphagia and xerostomia estimates closely while reducing optimization time from days to about one hour.
Ultra-high dose-rate proton DNA damage changed with scavenger concentration and dose
Ultra-high dose-rate protons produced fewer DNA breaks at low scavenger concentration, but the effect diminished or reversed under other experimental conditions.
Local control was similar across proton, photon and stereotactic radiotherapy for grade 1 meningioma
Five-year local control exceeded 89% across proton, photon and stereotactic approaches, with no significant modality effect in meta-regression.
Heart dose rises during esophageal IMPT but adaptive replanning limits the increase
Mean heart dose increased during esophageal IMPT, while heart-dose–triggered replanning reduced the excess dose in patients requiring adaptation.
Most European proton candidates still face critical access shortages
More than 56,000 theoretically eligible European patients lived in areas with no proton access or critical capacity shortages in 2025.
Deep learning reduced pediatric craniospinal target contouring from eight hours to 30 minutes
Automated pediatric CSI contours achieved a mean Dice score of 0.959 and reduced target-delineation time from approximately eight hours to 30 minutes.
Patient-informed design supported rapid and representative COMPPARE trial accrual
COMPPARE enrolled 2,524 patients from 51 institutions in 52 months, with Black participation reaching 16% of the cohort.
Online proton adaptation improved dosimetry but required about one hour per fraction
Adaptation would have improved organ sparing or target coverage in 46% of fractions, with a median workflow time of 61.9 minutes.
TLD-100 response varied systematically with synchrotron proton dose rate
TLD-100 over-responded below 7 Gy/s and under-responded above 300 Gy/s, despite remaining dose-independent from 3 to 18 Gy.
Protons produced greater subclinical lung changes after breast nodal irradiation
Proton therapy produced greater CT-detected lung changes than photons despite lower lung dose and no increase in clinical pulmonary toxicity.
High-dose chemotherapy was linked to radiographic brain injury after proton therapy for medulloblastoma
Radiographic brain injury occurred in 16% of children, all asymptomatic; every affected patient had received high-dose chemotherapy.