Online adaptive proton SBRT was feasible in the phase I PARTY trial
All 50 proton SBRT fractions were completed, with online adaptation used in 84% to restore target coverage or resolve OAR violations.
Tag
Protons
Bragg peak FLASH proton plans matched conventional IMPT dosimetry in skull-base tumors
Bragg peak FLASH achieved high ultra-high-dose-rate coverage with similar target coverage to conventional IMPT, but produced higher target and CNS hotspots.
Salvage proton therapy achieved durable control after prostate cryotherapy or HIFU failure
Ten-year biochemical control was 64.7% after salvage proton therapy, with 3.2% late grade 3 genitourinary toxicity.
Selective image guidance shortened decubitus proton CSI setup without reducing accuracy
Selective field-based imaging reduced mean setup time by about five minutes with similar geometric accuracy and dosimetric robustness.
FLASH proton therapy preserved ocular function without reducing short-term tumor control
FLASH protons largely preserved ocular structure and retinal function after 24 Gy while maintaining short-term tumor control in mice.
Breath-hold proton therapy was clinically feasible for mediastinal lymphoma
Across 187 fractions, surface-guided breath-hold IMPT remained highly stable, with only one patient requiring adaptive replanning.
Multicenter phantom testing detected and corrected adaptive proton therapy dose errors
A six-center end-to-end framework detected anatomy-induced proton dose deterioration and verified near-complete recovery after adaptive replanning.
Proton spot boosting improved prompt-gamma monitoring while largely preserving plan quality
Boosting selected proton spots reduced simulated prompt-gamma noise by up to 93.3% while maintaining acceptable target and organ-at-risk dosimetry.
Postoperative proton therapy achieved 84% five-year local control in paediatric ependymoma
Postoperative proton therapy achieved 84% five-year local control in paediatric ependymoma
Deep learning proton plans were clinically accepted for all 78 oropharyngeal patients
All 78 deep learning-generated IMPT plans were clinically accepted, with comparable or lower organ doses than manual benchmark plans.
Causal modeling suggested elevated proton RBE for mandibular osteoradionecrosis
Causal modeling estimated mandibular proton RBE at 1.61, 1.30 and 1.13 at 40, 50 and 60 GyRBE, respectively
Proton hemithoracic irradiation achieved major normal-tissue sparing with limited severe pneumonitis
Proton IMPRINT kept contralateral lung mean dose at 0.3 Gy, with grade 3 pneumonitis occurring in 6% of patients.
Proton hypofractionation achieved durable control in heavily reirradiated spine metastases
Proton hypofractionation produced 10% one-year local failure despite extensive prior irradiation, with grade 3 toxicity confined to multiply reirradiated patients.
Severe brainstem necrosis followed standard proton CSI in 22q11.2 deletion syndrome
A patient with 22q11.2 deletion developed refractory brainstem necrosis nine months after guideline-concordant proton craniospinal irradiation.
Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.