Dose-guided positioning optimized proton target coverage within three minutes
Automated dose-guided positioning matched anatomical alignment overall and improved primary target coverage by 1.0% when the clinical goal was initially missed.
Tag
Protons
FLASH proton therapy for lung cancer remains preclinical despite technical progress
Preclinical lung studies support normal-tissue sparing, but uncertain biological thresholds, dose conformity, and respiratory motion still prevent clinical implementation.
Protons reduced spinal cord and bowel dose in single-fraction spine SBRT plans
Proton plans preserved 20-Gy target coverage while reducing spinal cord, oesophageal, lung, and bowel dose compared with photon VMAT.
Combined dose–LET model predicted temporal lobe necrosis after skull-base proton therapy
Temporal lobe volumes receiving high dose or moderate dose with high LET jointly predicted grade 2 or higher necrosis.
Reinforcement learning adapted proton spot delivery across respiratory phases
Patient-specific reinforcement learning improved moving-target coverage over static GTV plans while reducing some normal-tissue exposure compared with ITV planning.
GPU dose engine calculated MRI-guided proton plans within 14 seconds
gPRIDE closely matched Monte Carlo calculations for most anatomies and completed MRI-guided proton dose calculations within 13.7 seconds.
Gold nanoparticles increased proton radiosensitivity without a clear size-dependent effect
Gold nanoparticles increased proton-induced clonogenic killing from 4 Gy onward, with similar sensitization using 20- and 50-nm particles.
RadComp protons lowered mean cardiac dose without improving early cardiac-related quality of life
Protons substantially reduced mean cardiac exposure, but no cardiac dose metric predicted patient-reported symptoms during the first six months.
Proton therapy reduced estimated immune-cell dose in postoperative esophageal radiotherapy
Estimated immune-cell dose predicted lymphocyte decline and was substantially lower with proton plans, particularly spot-scanning proton arc therapy.
Bragg peak proton FLASH matched CyberKnife plans and cut beam delivery to seconds
In 10 recurrent glioblastoma replans, Bragg peak proton FLASH improved conformity and reduced estimated beam delivery from approximately 17 minutes to under two seconds.
Robust IMPT modestly reduced organ-at-risk dose in five-fraction prostate proton therapy
SFUD and robust IMPT maintained target coverage under uncertainty, while IMPT modestly reduced rectal and bladder dose.
Spine proton ablative radiotherapy achieved 74% two-year local control in selected patients
Spine proton ablative radiotherapy achieved 74% local control at one and two years, with no radiation myelopathy in a reirradiation-enriched cohort.
Fraction 15 was optimal for one-time offline replanning in head and neck proton therapy
A single offline replan at fraction 15 captured most achievable dosimetric benefit in simulated head and neck proton therapy.
Surface-contacted 3D bolus plus MLC reduced proton PBS lateral penumbra
Surface-contacted 3D boluses generally narrowed lateral penumbra and reduced surrounding dose versus a nozzle-mounted range shifter in proton PBS.
Single-field optimization improved proton LATTICE motion robustness
Single-field optimization improved proton LATTICE motion robustness