Berberine increased radiation-induced DNA damage and tumor suppression in HNSCC models
Berberine enhanced radiation response in HNSCC models by increasing DNA damage and apoptosis while suppressing DNA repair and stemness pathways.
Tag
radiobiology
Metformin reshaped glioblastoma immunity and improved radiotherapy response in mice
Metformin plus radiotherapy prolonged survival in two syngeneic glioblastoma models while shifting macrophage and T-cell populations toward antitumor phenotypes.
S100A8/A9 blockade improved survival after abdominal irradiation in mice
Paquinimod blockade of S100A8/A9 improved survival, intestinal regeneration and barrier recovery after abdominal irradiation in preclinical models.
Cannabinoids reduced glioblastoma apoptosis after chemotherapy and radiation in vitro
Several cannabinoids reduced therapy-induced glioblastoma apoptosis and enhanced clonogenic survival in vitro, raising concern about concurrent use during treatment.
FLASH and conventional irradiation triggered similar mitochondrial remodeling in head and neck cancer cells
Both dose rates increased mitochondrial respiration after irradiation, with no clear FLASH-specific mitochondrial phenotype under normoxic conditions.
Ultra-high dose-rate proton DNA damage changed with scavenger concentration and dose
Ultra-high dose-rate protons produced fewer DNA breaks at low scavenger concentration, but the effect diminished or reversed under other experimental conditions.
CHAF1A promotes DNA repair and tumor radioresistance through RAD51 and KU70
CHAF1A supported homologous recombination and non-homologous end joining, while its depletion increased radiosensitivity in xenograft models.
Chemoradiotherapy and immunoradiotherapy reshape distinct esophageal cancer microenvironment programs
Chemoradiotherapy suppressed LAMC2–macrophage signalling, while immunoradiotherapy enriched CCL5-positive CD8 T cells in preclinical esophageal squamous-cell carcinoma models.
Two-dimensional TCP modeling linked lung tumour control mainly to radiosensitivity heterogeneity
Inter-patient radiosensitivity explained 85–97% of modeled TCP steepness, while uncertainty in delivered dose exceeded uncertainty in local-control estimates.
FLASH altered early molecular responses without improving breast cell survival
Electron FLASH changed DNA-damage, transcriptomic, cytokine, and microtubule responses but did not alter clonogenic survival under normoxic conditions.
USP15-FIS1 signaling sensitized bladder cancer to radiotherapy through mitochondrial dysfunction
USP15 stabilized FIS1, suppressed oxidative phosphorylation, and increased radiosensitivity; metformin restored radiation response in USP15-low bladder cancer models.
Oral copper chelation preserved salivary gland function after irradiation in mice
Systemic tetrathiomolybdate reduced collagen deposition and preserved saliva secretion after irradiation of mouse submandibular glands.
EQD2 remains essential but uncertain in modern cervical HDR brachytherapy
EQD2 should remain the reporting standard, but delivery time, dose gradients, biological assumptions and dose accumulation materially affect its interpretation.
FLASH reduced corneal injury after whole-brain irradiation in mice
FLASH preserved corneal thickness and collagen organization better than conventional irradiation at 10 and 15 Gy, but protection weakened at 20 Gy.
Review links chemoresistance and radioresistance through shared adaptive programmes
Chemotherapy and radiotherapy resistance may converge on shared DNA-repair, redox, metabolic, stemness and microenvironmental adaptations.