Oral copper chelation preserved salivary gland function after irradiation in mice
Systemic tetrathiomolybdate reduced collagen deposition and preserved saliva secretion after irradiation of mouse submandibular glands.
Tag
radiobiology
EQD2 remains essential but uncertain in modern cervical HDR brachytherapy
EQD2 should remain the reporting standard, but delivery time, dose gradients, biological assumptions and dose accumulation materially affect its interpretation.
FLASH reduced corneal injury after whole-brain irradiation in mice
FLASH preserved corneal thickness and collagen organization better than conventional irradiation at 10 and 15 Gy, but protection weakened at 20 Gy.
Review links chemoresistance and radioresistance through shared adaptive programmes
Chemotherapy and radiotherapy resistance may converge on shared DNA-repair, redox, metabolic, stemness and microenvironmental adaptations.
Carbon ions triggered distinct cell-cycle and chromatin transcriptional responses
At equal physical dose, carbon ions produced transcriptional changes distinct from X-rays, including stronger suppression of mitotic and chromatin-regulatory programmes.
FLASH preserved mitochondrial function in non-tumorigenic pancreatic models
FLASH spared mitochondrial integrity in non-tumorigenic pancreatic models while producing tumour effects comparable with conventional-dose-rate irradiation.
Circadian disruption may modify radiation-induced acute myeloid leukaemia risk
Circadian dysregulation could impair DNA repair and haematopoietic control after radiation exposure, but direct evidence linking it to acute myeloid leukaemia is lacking.
Review proposes harmonized reporting of biological dose across particle therapies
A translational review proposes shared reporting and quality-assurance principles for model-dependent biological dose in proton, carbon-ion and boron neutron capture therapy.
Timing shaped radiotherapy-immunotherapy synergy across mechanisms
This systematic review found that optimal radiotherapy-immunotherapy sequencing depends on the immune mechanism being targeted.
Immuno-Eclipse radiotherapy controlled bulky tumor models through antitumor immunity
Immuno-Eclipse radiotherapy improved bulky tumor control in mice through natural killer and cytotoxic T-cell immunity.
Scanned and scattered proton beams showed similar tumor killing in Ewing sarcoma models
Scanned and scattered clinical proton beams produced similar Ewing sarcoma cell survival despite higher oxidative stress signals after scanned delivery.
Regional lymph node irradiation altered immune responses after sinonasal stereotactic radiotherapy in dogs
Regional lymph node irradiation was linked to attenuated local cytokine shifts and nodal damage and cell-death signatures after sinonasal stereotactic radiotherapy.
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.
Convergent 60 keV photons show cell-dependent biological effectiveness
Convergent 60 keV photons matched orthovoltage radiation and showed comparable or greater biological effectiveness than 6 MV photons, depending on cell type.
Ultrahigh dose-rate protons reduce hydrogen peroxide yield in water
Hydrogen peroxide production decreased as proton dose rate increased, with Geant4-DNA simulations reproducing the oxygen-dependent experimental trend.