Glutathione S-transferase mu 3 limits testicular injury after ultrahigh dose-rate irradiation
In mice, ultrahigh dose-rate X-rays caused less early testicular damage than conventional irradiation, with protection linked to ferroptosis suppression.
Tag
radiobiology
Insufficient ferroptosis promoted regulatory T-cell accumulation and radiotherapy resistance
Radioresistant tumors showed impaired ferroptosis and regulatory T-cell accumulation, while sorafenib enhanced the response to irradiation in mice.
FLASH radiotherapy reduced hepatic injury in a murine breast cancer model
FLASH radiotherapy preserved hepatic structure and metabolic homeostasis while maintaining tumor control in a preclinical breast cancer model.