KRAS mutation did not worsen intracranial control after SRS for NSCLC brain metastases
KRAS-mutant and wild-type NSCLC showed similar intracranial control after SRS, while higher radiation dose predicted better outcomes.
Tag
SRS
SMART planning reduced memory-circuit dose during SRS for ≥10 brain metastases
SMART reduced mean memory-circuit dose from 2.9 to 1.8 Gy while maintaining greater than 95% target coverage.
Brain metastasis SRS fractionation varied widely across Turkish radiation oncologists
Tumor volume and OAR proximity drove brain metastasis fractionation, while preoperative SRS showed a substantial preference-to-practice gap.
SRT did not improve survival over whole-brain radiotherapy after matching in SCLC
After propensity matching, SRT did not improve survival over WBRT, while adding a boost showed a non-robust intracranial control signal.
Brainlab reference beam model enabled one-day SRS commissioning with accurate Monte Carlo calculations
Brainlab Elements commissioning was completed in one day, while Monte Carlo generally agreed with end-to-end measurements within 3%.
ESTRO review supports selective CNS reirradiation but highlights cumulative-dose limits
ESTRO supports individualized reirradiation for selected recurrent brain tumors, with cumulative dose, target volume and critical structures determining feasibility.
Local control was similar across proton, photon and stereotactic radiotherapy for grade 1 meningioma
Five-year local control exceeded 89% across proton, photon and stereotactic approaches, with no significant modality effect in meta-regression.
Individual target optimization reduced brain dose in single-isocenter multi-metastasis radiosurgery
Individual target optimization lowered normal-brain V12 and improved dose gradients while maintaining over 99% coverage, at the cost of higher monitor units.
Twenty-two Gy SRS was associated with better brain metastasis control than 20 Gy
Single-fraction 22 Gy SRS achieved higher one-year local control than 20 Gy, although retrospective dose selection creates important confounding.
Submillimetre MLC errors substantially altered HyperArc brain metastasis dose
A 1 mm symmetric MLC closing reduced minimum GTV dose by 25%, while translations caused cumulative target undercoverage.
Preoperative stereotactic radiotherapy shortened brain metastasis treatment without increasing early morbidity
Preoperative SRS/FSRT completed local therapy 22.5 days sooner than postoperative treatment, with similar 30-day morbidity; oncologic outcomes remain pending.
One RapidPlan model generated ocular stereotactic plans across three fractionation schedules
A single knowledge-based model generated comparable ocular plans for 25 Gy once, 42 Gy in three fractions and 50 Gy in five.
Brain metastasis contouring variability depended on lesion and MRI factors
Brain metastasis contours showed generally high agreement, although lesion volume, oedema and magnetic resonance imaging field strength influenced variability.
Late radiation necrosis after stereotactic radiosurgery temporally associated with COVID-19 vaccination
A case report describes pathology-confirmed late radiation necrosis after stereotactic radiosurgery, with radiographic progression temporally associated with repeated COVID-19 vaccination.
Aperture-enhanced proton radiosurgery reduced normal brain dose for cerebral arteriovenous malformations
Aperture-enhanced proton stereotactic radiosurgery reduced normal brain dose compared with photon plans in most cerebral arteriovenous malformation cases.