HyperSight CBCT approached simulation-CT dosimetry for offline adaptive breast radiotherapy
HyperSight reduced PTV dose-recalculation deviations versus Halcyon 3.1 while using a lower imaging dose in 12 breast radiotherapy patients.
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technical-relevance
Maskless SGRT improved initial pelvic setup and shortened positioning time
Maskless SGRT reduced initial setup error and cut mean positioning time by about 29% compared with thermoplastic-mask alignment.
No lung subregion strategy clearly improved radiation pneumonitis prediction
Whole-lung, physical-dose and BED3 models performed similarly externally, with the best complete-model AUC only 0.684 and inadequate calibration.
Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.
Antiscatter grid sharply improved proton CBCT accuracy and soft-tissue contrast
A 2D antiscatter grid reduced soft-tissue CT-number error from 169 to 38 HU at unchanged imaging dose.
Mechanistic model predicted six-month lymphocyte depletion after lung SBRT
A circulation-based model predicted post-SBRT lymphocyte trajectories and linked a higher predicted lymphocyte nadir with better survival.
Daily skin variation caused substantial target underdose in kidney proton SABR
Daily surface changes shifted proton beam depth by up to 17.4 mm and reduced accumulated target D99 by up to 24.3%.
VMAT-based pediatric TBI achieved organ sparing with acceptable early clinical outcomes
VMAT-TBI achieved 96.6% mean PTV D95 while keeping mean lung and kidney doses below 9 Gy.
Breathing-phase targeting reduced normal-tissue dose in proton lung radiotherapy
Planning on selected respiratory phases reduced lung, heart and esophageal dose, but the optimal phase differed by toxicity endpoint.
Fat saturation destabilized most MRI radiomics features used for radionecrosis prediction
Only 10.7% of T2 MRI radiomics features remained highly stable across fat-saturation protocols, and stability filtering improved prediction.
Complex deformable dose accumulation rarely changed adaptive SBRT decisions
More accurate deformable registration lowered estimated bowel dose, but produced nearly identical in-treatment adaptation decisions to simple DVH summation.
LET-optimized proton arc planning more than doubled the lattice peak-to-valley dose ratio
PATLESL increased lattice peak-to-valley dose ratio from 16.9 to 41.9 while reducing spot number and delivery time.
Beam-deflection compensation restored proton dose delivery inside an in-beam MR scanner
Energy-layer-wise compensation restored millimetre-level proton targeting despite magnetic-field beam shifts approaching 30 mm in an MR-integrated prototype.
Reducing tomotherapy modulation beyond the gantry plateau saved almost no treatment time
The pre-plateau modulation factor preserved plan quality while further reduction created idle delivery time without meaningful efficiency gain.
Low-dose brain exposure diverged sharply between SRT platforms as metastasis number increased
CyberKnife best contained low-dose spread at high lesion burdens but required substantially longer treatment than faster VMAT strategies.