Large target and heart volumes predicted replanning during proton therapy for thoracic cancer
In 180 thoracic proton therapy patients, larger clinical target volume and heart volume independently predicted the need for adaptive replanning.
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Technical relevance
Monte Carlo simulations identified depth-specific settings for proton minibeam radiation therapy
Simulated proton minibeams preserved spatial fractionation and target homogeneity for targets up to 20 centimetres with depth-adapted beam widths and spacing.
Intrafractional motion frequently exceeded tolerance during multi-target stereotactic radiosurgery
After 66% of couch-angle changes, motion exceeded tolerance, and 0.5-millimetre and 0.5-degree errors reduced near-minimum target dose by 7.6%.
Automated volumetric modulated arc therapy planning improved organ-at-risk sparing in head and neck radiotherapy
Across 500 clinical cases, automated planning preserved target coverage and was associated with lower doses to multiple critical structures than earlier manual planning.
Respiratory motion remained small during postoperative whole-breast radiotherapy.
Mean breast target displacement was below 1.3 mm in every direction, with calculated respiratory margins of approximately 1 mm.
Conventional fractionation substantially reduced gastrointestinal motility–driven interplay in pancreatic proton therapy.
Gastrointestinal motility reduced single-fraction target coverage and broadened organ-at-risk dose ranges, while conventional fractionation substantially attenuated the interplay effect.
Multimodal respiratory tracking enabled real-time voxel-wise anatomical reconstruction during radiotherapy
The patient-specific framework outperformed three comparison methods and reconstructed respiratory anatomy in 15.6 milliseconds per frame.
Electromagnetic tracking enabled sub-5-mm magnetic resonance imaging–ultrasound guidance in gynecologic brachytherapy
Live magnetic resonance imaging–ultrasound fusion achieved under 4 mm registration accuracy and under 5 mm needle localization in two clinical implants.
Weekly synthetic computed tomography identified structure-specific replanning triggers in nasopharyngeal carcinoma
Weekly monitoring identified week 2 triggers for nodal targets and contralateral parotids, with later week 4 triggers for primary targets.
K-means rapidly optimized isocenters and margins for polymetastatic stereotactic ablative radiotherapy
K-means matched hybrid optimization for margin volume while reducing median computation time from 306.9 seconds to 0.19 seconds.
Virtual contrast-enhanced MRI matched gadolinium-enhanced imaging for diagnosis, staging, and tumor delineation.
98.98% of virtual contrast-enhanced MRI scans were rated suitable for diagnosis, and 92.33% for tumor delineation.
Physics-constrained network improved cone-beam computed tomography reconstruction from orthogonal pelvic radiographs
A physics-constrained network reconstructed pelvic cone-beam computed tomography from two simulated radiographs with substantially lower error than generative baselines.
Respiratory gating limited accumulated motion-related dose errors in proton therapy for hepatocellular carcinoma
Respiratory gating more than halved cranio-caudal motion, while motion-related target-dose deviations largely diminished after accumulation across more than three fractions.
DGMP toolkit finds no single method sufficient for stereotactic radiotherapy quality assurance
No single patient-specific quality assurance method covered all stereotactic radiotherapy risks, supporting combinations of measurement, independent calculation, imaging, and monitoring.
Surface scans showed modest average but substantial individual breast deformation during radiotherapy
Mean treated-breast displacement was 1.6 mm, with larger patient-specific changes near treatment completion and during follow-up.