A 3D-printed jig enabled small-animal irradiation with clinical iridium-192
A 3D-printed jig delivered approximately uniform iridium-192 tumor dose, delayed tumor growth, and caused no observable short-term radiation toxicity in mice.
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Technical relevance
Hybrid respiratory gating mitigated interplay in spot-scanning proton therapy
Hybrid phase-amplitude gating restored dose agreement during regular motion, while irregular breathing increased treatment time and produced inconsistent accuracy.
Off-axis beam optimization reduced lung dose in posterior lung stereotactic body radiotherapy
Off-axis beam optimization preserved target coverage while reducing lung dose and enabling collision-free beam geometry for posterior lung lesions.
Robust optimization reduced organ doses in long-course lung radiotherapy
Robust optimization preserved target coverage while reducing lung, heart, esophageal, spinal cord, and estimated immune-cell dose during long-course lung radiotherapy.
Failure analysis identifies target definition and motion management as key risks in stereotactic arrhythmia radioablation
Multimodal registration, motion management, and arrhythmia substrate definition were the highest-risk steps in stereotactic arrhythmia radioablation.
Neural model compresses proton Monte Carlo phase-space data while preserving dose accuracy
The neural model reduced phase-space storage from 3 gigabytes to 600 kilobytes while maintaining at least 89.9% gamma passing at 1%/1 mm.
Large language model framework extracted cardiac events with up to 85.5% accuracy
The framework achieved 85.5% external-validation accuracy and reduced estimated review time from 822 hours to 2.3–4.8 hours.
Tissue heterogeneity substantially alters absorbed dose in intraoperative radiotherapy
Absorbed dose near the applicator varied markedly by tissue composition despite accurate Monte Carlo calculation by the treatment planning system.
End-to-end test achieved high dosimetric agreement across adaptive platforms
A reusable phantom-based test verified simulation-omitted adaptive workflows on cone-beam computed tomography-guided and magnetic resonance-guided treatment systems.
CyberKnife reduced low-dose exposure in left-sided partial-breast irradiation
CyberKnife improved conformity and reduced cardiac, pulmonary, and low-dose exposure, while noncoplanar linac techniques remained clinically acceptable alternatives.
Knowledge-based prostate planning transfers across fractionation regimens with comparable plan quality
A conventional-fractionation model produced clinically acceptable moderately hypofractionated prostate plans, with comparable overall quality and slightly reduced target homogeneity.
Commercial lung phantom density errors can reduce target coverage by 3%
Lot-to-lot density variation in lung-equivalent inserts reduced planning target volume coverage by up to 3%, exceeding the stated clinical tolerance.
Low monitor unit deliveries show pulse-limited variability on a modern linear accelerator
Discrete pulse counts limited fractional monitor unit precision, particularly for high-dose-per-pulse flattening filter-free beams.
Ultrahigh dose-rate protons reduce hydrogen peroxide yield in water
Hydrogen peroxide production decreased as proton dose rate increased, with Geant4-DNA simulations reproducing the oxygen-dependent experimental trend.
Monocular surface imaging enables real-time breast dose reconstruction
Patient-specific surface imaging reconstructed breast radiotherapy dose with a 93.8% gamma passing rate and 42-millisecond latency without additional imaging radiation.