Dynamic IMRT shortened left-breast DIBH delivery while limiting low-dose exposure
Dynamic tangential IMRT delivered left-breast DIBH 42% faster than VMAT with similar target coverage and lower low-dose normal-tissue exposure.
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Technical relevance
AI supported an MRI-only prostate planning workflow with near-identical dose calculation
AI-generated synthetic CT achieved 99.8% gamma agreement with conventional CT while automated pelvic contours remained within expert interobserver variability.
Proton spot boosting improved prompt-gamma monitoring while largely preserving plan quality
Boosting selected proton spots reduced simulated prompt-gamma noise by up to 93.3% while maintaining acceptable target and organ-at-risk dosimetry.
CBCT dose changes predicted adaptive radiotherapy benefit better than volume changes
Week-three CBCT dose changes predicted head and neck adaptive radiotherapy benefit with AUC 0.78 versus 0.54 using volume changes.
Most salvage prostate radiotherapy plans met SPPORT and RADICALS-HD dose constraints
Most multicenter salvage prostate radiotherapy plans met SPPORT and RADICALS-HD organ constraints, with smaller bladder volumes linked to more violations.
Smaller sequential brachytherapy applicators improved dose uniformity on curved surfaces
Smaller modular superficial brachytherapy applicators and sequential placement substantially improved dose uniformity, especially for beta-emitting sources.
Deep learning proton plans were clinically accepted for all 78 oropharyngeal patients
All 78 deep learning-generated IMPT plans were clinically accepted, with comparable or lower organ doses than manual benchmark plans.
Causal modeling suggested elevated proton RBE for mandibular osteoradionecrosis
Causal modeling estimated mandibular proton RBE at 1.61, 1.30 and 1.13 at 40, 50 and 60 GyRBE, respectively
HyperSight CBCT approached simulation-CT dosimetry for offline adaptive breast radiotherapy
HyperSight reduced PTV dose-recalculation deviations versus Halcyon 3.1 while using a lower imaging dose in 12 breast radiotherapy patients.
Maskless SGRT improved initial pelvic setup and shortened positioning time
Maskless SGRT reduced initial setup error and cut mean positioning time by about 29% compared with thermoplastic-mask alignment.
No lung subregion strategy clearly improved radiation pneumonitis prediction
Whole-lung, physical-dose and BED3 models performed similarly externally, with the best complete-model AUC only 0.684 and inadequate calibration.
Structured cumulative-dose review triggered replanning in one-quarter of proton reirradiation cases
Voxel-wise cumulative EQD2 review prompted reoptimization in 25.5% of proton reirradiation courses and exposed frequent registration problems.
Antiscatter grid sharply improved proton CBCT accuracy and soft-tissue contrast
A 2D antiscatter grid reduced soft-tissue CT-number error from 169 to 38 HU at unchanged imaging dose.
Mechanistic model predicted six-month lymphocyte depletion after lung SBRT
A circulation-based model predicted post-SBRT lymphocyte trajectories and linked a higher predicted lymphocyte nadir with better survival.
Daily skin variation caused substantial target underdose in kidney proton SABR
Daily surface changes shifted proton beam depth by up to 17.4 mm and reduced accumulated target D99 by up to 24.3%.