A multidisciplinary roadmap defines the safety, imaging and research requirements needed before upright radiotherapy can be adopted more broadly in children.
In 93 glioma cases, a five-parameter CTV model reproduced physician contours and achieved similar blinded clinical quality ratings.
SPC-guided planning reduced larynx and parotid doses without compromising target coverage in a 200-patient retrospective nasopharyngeal carcinoma series.
Median online adaptive MR-guided treatment time fell 28% despite increasing complexity, with 78% of late-era fractions completed within 60 minutes.
Selective field-based imaging reduced mean setup time by about five minutes with similar geometric accuracy and dosimetric robustness.
Adding functional brain regions to CyberKnife optimization reduced dose to multiple structures by roughly 23%–39% while preserving target coverage.
Obturator nodes received about 75% of the prescribed bladder dose incidentally, with similar regional exposure from VMAT and fixed-field IMRT.
Second-generation AI reduced rectal radiotherapy contouring time from 41 to 17 minutes while improving accuracy and consistency.
Environ showed less static-beam attenuation and lower vertical setup variability than Encompass while maintaining accurate HyperArc dose calculation.
Calibrated uncertainty thresholds kept gamma-defined dose-modelling failure below 10% while accepting 45–77% of irradiation segments.
Mechanical ventilation reduced median liver motion from 29 mm during free breathing to 9 mm at 60 breaths per minute with PEEP.
Restricting deep VMAT apertures reduced heart and ipsilateral lung exposure across three linacs while maintaining comprehensive breast and nodal coverage.
Across 187 fractions, surface-guided breath-hold IMPT remained highly stable, with only one patient requiring adaptive replanning.
VMAT exposed less circulating blood than IMRT, but modeled immune-cell depletion differed by only one percentage point after 30 fractions.
A six-center end-to-end framework detected anatomy-induced proton dose deterioration and verified near-complete recovery after adaptive replanning.