Pencil-beam scanning proton re-irradiation showed low acute toxicity in recurrent head and neck cancer
Pencil-beam scanning proton re-irradiation achieved 17.2-month median survival with 7.7% grade 3 or higher oral mucositis.
Tag
toxicity
Tumor treating field arrays increased surface dose during photon radiotherapy
Tumor treating field arrays caused substantial surface dose enhancement and measurable dose attenuation during 6-megavolt photon irradiation.
Hydrogen gas inhalation showed exploratory metabolic and toxicity signals during head and neck chemoradiotherapy
Adjunctive hydrogen gas inhalation was associated with numerically fewer moderate toxicities and exploratory serum metabolomic changes during head and neck chemoradiotherapy.
International consensus supported acute radiation dermatitis scoring tool
An international Delphi panel approved a three-step acute radiation dermatitis tool integrating patient-reported symptoms and clinician assessment.
Dose-dependent linear energy transfer constraints supported proton toxicity interpretation
Dose-dependent linear energy transfer constraints aligned with published proton toxicity data better than fixed threshold approaches.
Boswellia serrata was associated with acute kidney injury during radiation necrosis treatment
A case report linked high-dose Boswellia serrata use for radiation necrosis with reversible acute kidney injury.
Thyroid complication models showed only moderate long-term validation in head and neck cancer
Existing thyroid complication models showed moderate performance and frequent miscalibration in long-term head and neck cancer survivorship.
Computed tomography radiomics showed exploratory recurrence signals in mandibular osteoradionecrosis
In 24 surgically confirmed cases, three radiomic features differed nominally between pure osteoradionecrosis and osteoradionecrosis with recurrence.
Preoperative radiotherapy did not worsen renal function after retroperitoneal sarcoma surgery
Preoperative radiotherapy was not associated with greater renal dysfunction after nephrectomy for retroperitoneal sarcoma during follow-up extending to 80 months.
Early diffusion changes precede brain lesions after proton therapy for low-grade glioma
Regional diffusion changes distinguished patients who developed contrast-enhancing brain lesions as early as six months after proton therapy.
Body composition adds little to radiotherapy toxicity prediction
Computed tomography-derived muscle measures ranked highly for toxicity and quality of life, but added little predictive value beyond established clinical factors.
Glutathione S-transferase mu 3 limits testicular injury after ultrahigh dose-rate irradiation
In mice, ultrahigh dose-rate X-rays caused less early testicular damage than conventional irradiation, with protection linked to ferroptosis suppression.
Ultrahigh dose-rate radiotherapy still requires conformal planning and conservative dose constraints
Normal-tissue sparing with ultrahigh dose-rate radiotherapy remains conditional and cannot replace conformal dosimetry, organ-at-risk constraints, or rigorous quality assurance.
Risk-adapted esophagus sparing reduces dose with low severe esophagitis in lung cancer
Risk-adapted esophagus-sparing radiotherapy maintained target coverage, with grade 3 esophagitis in only 1.25% of high-risk patients.
Bone marrow-sparing radiotherapy lowers pelvic marrow dose without proven toxicity reduction
Bone marrow-sparing planning reduced pelvic marrow dose, but heterogeneous evidence did not confirm a consistent reduction in hematologic toxicity.