Immune-sparing lung SBRT planning reduced lymphocyte loss in a randomized phase II trial
Optimizing dose to blood- and immune-rich structures reduced lymphocyte depletion and prevented grade 3 lymphopenia after early-stage lung SBRT.
Tag
toxicity
Proton therapy reduced estimated immune-cell dose in postoperative esophageal radiotherapy
Estimated immune-cell dose predicted lymphocyte decline and was substantially lower with proton plans, particularly spot-scanning proton arc therapy.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction has the strongest evidence, while proton therapy and immunotherapy-based de-escalation remain less established.
FLASH reduced corneal injury after whole-brain irradiation in mice
FLASH preserved corneal thickness and collagen organization better than conventional irradiation at 10 and 15 Gy, but protection weakened at 20 Gy.
Skin microbiome signatures were associated with moderate-to-severe breast radiodermatitis
Clostridium, Anaerococcus US436 and Granulicatella elegans were associated with moderate-to-severe acute dermatitis during breast radiotherapy.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction and sequential chemoradiotherapy have the strongest evidence, while proton and immunotherapy-based approaches remain less established.
Five-fraction whole-breast irradiation showed low short-term toxicity across 28 Italian centres
Whole-breast irradiation with 26 Gy in five fractions produced mainly grade 1 toxicity in 2,036 patients, including those receiving a boost.
Five-fraction prostate and pelvic nodal SBRT showed low late toxicity
After prostate and pelvic nodal SBRT, no grade ≥3 late GU or GI toxicity occurred among 101 patients with high-risk disease.
Lower microvascular health predicted acute radiotherapy toxicity across three cancer cohorts
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
Pelvis-inclusive SBRT reduced acute gastrointestinal toxicity in high-risk prostate cancer
Once-weekly prostate-and-pelvis SBRT reduced acute gastrointestinal toxicity versus conventional IMRT without significantly increasing genitourinary toxicity.
Concurrent polatuzumab vedotin and radiotherapy showed no unexpected toxicity in B-cell lymphoma
Concurrent polatuzumab vedotin and radiotherapy was feasible in heavily pretreated aggressive B-cell lymphoma without unexpected acute or subacute toxicity.
Twice-weekly 28 Gy whole-breast irradiation showed low toxicity in early breast cancer
Twice-weekly 28 Gy in 5 fractions produced no grade 3 or higher toxicity and 98.8% excellent-to-good cosmesis at 1 year.
Fat necrosis remained low after single-fraction stereotactic partial breast irradiation
Single-fraction GammaPod partial breast irradiation produced 12.1% fat necrosis and 4.1% symptomatic fat necrosis in a phase 2 trial.
Thoracic radiotherapy with atezolizumab increased toxicity in extensive-stage small cell lung cancer
TREASURE found no survival benefit and higher serious toxicity with thoracic radiotherapy added to atezolizumab maintenance.
Radiotherapy was tolerated without unexpected skin toxicity in epidermolysis bullosa
Four epidermolysis bullosa patients tolerated radiotherapy without greater-than-expected cutaneous toxicity, despite maximum skin dose up to 50.4 Gy.