Adjuvant radiotherapy added no survival benefit in modern melanoma treatment
Adjuvant radiotherapy did not improve recurrence-free or overall survival, but concurrent systemic therapy did not increase radiotherapy-related toxicity.
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Clinicians underestimated symptoms during radiotherapy for brain metastases
Patients reported greater symptom burden than clinicians in 84% of matched domains, with the largest gaps in psychological and less visible symptoms.
Breast edema appeared after the first fraction in 5-fraction radiotherapy
CBCT detected breast edema in 37.1% during 26 Gy in five fractions, usually immediately after the first treatment.
Daily low-dose cisplatin chemoradiotherapy remained feasible in older stage III NSCLC
Patients >70 receiving 66 Gy with daily low-dose cisplatin had survival and severe toxicity similar to younger patients in this retrospective cohort.
Cardiac avoidance area dose was associated with survival after oesophageal radiotherapy
Maximum cardiac avoidance area dose below 43.5 Gy was associated with longer median survival after curative-intent oesophageal radiotherapy.
Locoregional radiotherapy was associated with longer survival in de novo metastatic HNSCC
In de novo metastatic HNSCC, locoregional radiotherapy and first-line immunotherapy were independently associated with longer overall survival.
Trismus persisted in 35% of head and neck cancer survivors 10 years after radiotherapy
Ten years after radiotherapy, 35% of long-term head and neck cancer survivors had trismus with persistently worse quality of life.
Coronary intravascular brachytherapy prolonged restenosis-free intervals after recurrent in-stent restenosis
Median restenosis-free interval increased from 96 to 350 days after intravascular brachytherapy for repeatedly recurrent coronary in-stent restenosis.
Older patients maintained recurrence control after definitive anal cancer chemoradiotherapy
Patients aged ≥70 had similar recurrence outcomes after definitive chemoradiotherapy despite inferior overall survival and greater competing mortality.
International consensus standardizes 3D target volumes for low-dose RT of tendinitis and bursitis
IBTVG experts defined reproducible CT-based GTV, CTV and PTV concepts for common tendinitis and bursitis sites treated with low-dose radiotherapy.
Paediatric radiotherapy access improved globally, but major disparities persist
A decade after the previous IAEA survey, access to modern paediatric radiotherapy improved, but substantial technology, imaging and workforce disparities remain.
Machine learning showed moderate external prediction of hypothyroidism after head and neck radiotherapy
Random forest reached external AUC 0.769 for 12-month radiation-induced hypothyroidism, but calibration and clinical utility weakened outside the development center.
Whole-breast irradiation after perioperative brachytherapy showed no local relapses in selected patients
Among 26 patients receiving whole-breast irradiation after perioperative brachytherapy, 5-year local-relapse-free survival was 100% with no grade ≥3 toxicity.
Wilms tumor survivors had nearly threefold higher metabolic syndrome prevalence
Metabolic syndrome affected 18.8% of Wilms tumor survivors versus 7.3% of matched controls, with abdominal radiotherapy emerging as an important risk factor.
Cardiovascular events affected 59% after definitive lung cancer chemoradiotherapy
Cardiovascular events occurred in 59% after definitive lung chemoradiotherapy, while higher heart V20 and V30 independently tracked with greater event risk.