Immunotherapy-based TNT eliminated nodal disease in ypT0–1 rectal tumours
No positive lymph nodes were found in ypT0–1 tumours after immunotherapy-based TNT, supporting further study of local excision.
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Worth Attention
A 55-gene hypoxia signature identified poor-prognosis cervical cancer across cohorts
A 55-gene hypoxia classifier independently predicted worse survival and retained prognostic value across Manchester, Seoul, and Norwegian cervical cancer cohorts.
Different factors predicted cardiac-event subtypes after hypofractionated breast radiotherapy
Planning-CT calcification and age predicted atherosclerotic events, while anthracyclines and respiratory toxicity predicted other cardiac complications.
Five-fraction prostate SBRT showed low severe toxicity across Austrian centres
Linac-based 40 Gy in five fractions produced low severe toxicity and rapid urinary recovery across seven centres, although follow-up remained short.
Vaginal D2cc predicted late toxicity after EBRT plus cuff brachytherapy
Higher vaginal D2cc and target-dose distribution independently predicted grade 1–2 vaginal toxicity after combined external-beam radiotherapy and cuff brachytherapy.
Proton therapy reduced estimated immune-cell dose in postoperative esophageal radiotherapy
Estimated immune-cell dose predicted lymphocyte decline and was substantially lower with proton plans, particularly spot-scanning proton arc therapy.
Glioblastoma brachytherapy remains limited by non-standardized dosimetry
Modern intracavitary platforms can intensify pericavitary dose immediately after surgery, but standardized patient-specific dosimetry and comparative clinical evidence remain lacking.
PROTEUS improved composite MFS but not conventional imaging-defined MFS
Perioperative apalutamide improved pathological response and composite MFS, but not conventional imaging-defined MFS, raising concern about overtreatment in broadly defined high-risk disease.
Bone metastasis trials need treatment-intent endpoints beyond pain response
Pain should remain central for symptomatic disease, but prevention, function, local control and skeletal events require separate standardized endpoints.
Pelvic radiotherapy was associated with modest excess secondary uterine cancer risk
Twenty-year secondary uterine cancer incidence increased after pelvic radiotherapy, but absolute excess risk remained below two percentage points.
Five-fraction prostate radiotherapy showed low severe toxicity in men aged 75 or older
Five-fraction prostate radiotherapy achieved 82% three-year biochemical control with very few grade 3 toxicities in men aged 75 or older.
Prostate SABR practice varied despite broad adoption across Australia and New Zealand
Most surveyed oncologists offered prostate SABR, but patient selection, target volumes, focal boosts and access to supporting technology varied.
Knowledge-based breast VMAT achieved low heart doses and no grade 3 toxicity
A standardized knowledge-based VMAT workflow achieved high target coverage, low cardiopulmonary doses and no grade 3 acute toxicity in 484 patients.
Five-fraction prostate radiotherapy reduced estimated carbon emissions by 59%
Five-fraction prostate radiotherapy produced 58.6% lower estimated carbon emissions than a 26-fraction schedule, mainly by reducing patient travel.
Five-fraction whole-breast irradiation showed low short-term toxicity across 28 Italian centres
Whole-breast irradiation with 26 Gy in five fractions produced mainly grade 1 toxicity in 2,036 patients, including those receiving a boost.