Treatment interruptions were associated with poorer early outcomes during lung cancer radiotherapy
Unplanned radiotherapy interruptions occurred in 35% and were associated with lower response, more toxicity and markedly worse six-month survival.
Tag
Worth Attention
Baseline lymphocyte count predicted severe lymphopenia better than dosimetry in rectal cancer
Severe lymphopenia occurred in 44%, while baseline and week-2 lymphocyte counts outperformed 600 dosimetric variables for risk prediction.
Dose-escalated prostate SBRT was associated with worse late urinary quality of life
Late urinary worsening occurred in 80% after >40 Gy prostate SBRT versus 68% after ≤40 Gy, while bowel outcomes remained similar.
Organ preservation after immunotherapy-based TNT was linked to better bowel function
Organ preservation after immunotherapy-based TNT was associated with better quality of life and markedly lower risk of major bowel dysfunction than TME.
CT-based cervical brachytherapy achieved 84% five-year local control
Routine CT-based adaptive brachytherapy achieved 84.4% five-year local control despite 56.9% of patients having stage III–IV cervical cancer.
Twenty-fraction head and neck radiotherapy was feasible in older and comorbid patients
Ninety-five percent completed 55 Gy in 20 fractions, with encouraging outcomes in early p16-positive oropharyngeal cancer despite substantial acute toxicity.
Daily MR-guided salvage radiotherapy showed low severe toxicity after prostatectomy
Daily adaptive salvage radiotherapy produced 6% new grade ≥2 urinary toxicity at 12 months in a prospective 51-patient cohort.
Neoadjuvant chemoradiotherapy was associated with better survival in locally advanced gastric cancer
Neoadjuvant chemoradiotherapy achieved 26.5% pathological complete response and 80.4% five-year survival, outperforming chemotherapy-based strategies in this retrospective cohort.
Postoperative proton therapy achieved 84% five-year local control in paediatric ependymoma
Postoperative proton therapy achieved 84% five-year local control in paediatric ependymoma
Hemithoracic radiotherapy after surgery achieved durable control in pleural thymoma
After surgery and 14 Gy hemithoracic radiotherapy, five-year progression-free survival was 50.8% with only one grade 3 pneumonitis.
Low-dose radiotherapy showed very low in-field solid cancer incidence after musculoskeletal treatment
Only three in-field solid malignancies occurred among 4,699 patients, while marrow-adjacent irradiation was associated with slightly more hematologic malignancies.
Salvage HDR brachytherapy had low severe toxicity but limited five-year biochemical control
Five-year PSA progression-free survival was 24.8% after two-fraction salvage HDR brachytherapy without androgen deprivation, despite low severe toxicity.
Persistent internal mammary nodes on MRI identified patients associated with benefit from boost
Internal mammary node boost was associated with better disease-free survival only when MRI showed residual nodal disease after neoadjuvant therapy.
REQUITE revealed persistent toxicity and sex-specific symptom patterns after lung radiotherapy
Prospective REQUITE data showed substantial pulmonary toxicity after lung radiotherapy, with several sex-specific differences in symptoms and recovery.
Gamma Knife and LINAC radiosurgery produced similar vestibular schwannoma outcomes
Gamma Knife and LINAC radiosurgery produced similarly high control and low new neurologic symptoms in 85 vestibular schwannoma patients.