Bowel dose predicted acute diarrhea after both RAPIDO neoadjuvant strategies
Larger irradiated bowel volumes predicted acute diarrhea after both short-course total neoadjuvant treatment and chemoradiation, although discrimination was modest.
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Local control was similar across proton, photon and stereotactic radiotherapy for grade 1 meningioma
Five-year local control exceeded 89% across proton, photon and stereotactic approaches, with no significant modality effect in meta-regression.
Individual target optimization reduced brain dose in single-isocenter multi-metastasis radiosurgery
Individual target optimization lowered normal-brain V12 and improved dose gradients while maintaining over 99% coverage, at the cost of higher monitor units.
Baseline extracellular-vesicle microRNAs were associated with breast radiotherapy toxicity
Baseline miR-144-5p and miR-222-3p differed in patients who later developed greater radiation toxicity, but the signals require validation.
Iridium-192 boost improved progression-free survival in unresectable hilar cholangiocarcinoma
An iridium-192 boost increased median progression-free survival from 8.6 to 11.2 months, without a significant overall-survival improvement.
Prototype brachytherapy devices combined local radiation, hyperthermia and drug delivery concepts
A prototype stent increased dislodgement resistance 15-fold and demonstrated controllable heating, but proposed radiation-dose benefits remain experimentally untested.
On Ethos, intensity-modulated radiotherapy generated faster and spared several pelvic organs better than arc therapy
Nine-field intensity-modulated radiotherapy shortened overall planning-plus-delivery time and improved several pelvic dose metrics compared with volumetric modulated arc therapy.
Deep learning generated deliverable lymphoma intensity-modulated plans but remained dosimetrically inferior
Deep learning produced machine-deliverable lymphoma plans across heterogeneous anatomy, but target coverage and hot spots remained inferior to reference planning.
Audit logs measured artificial intelligence contour correction time with 0.93 concordance
Treatment-planning audit logs closely reproduced manual contour-edit timing and exposed major structure-specific differences in correction workload.
Longitudinal muscle loss and myocardial remodeling tracked worse survival after non-small cell lung cancer radiotherapy
Skeletal muscle loss and substantial left ventricular mass changes on follow-up imaging were strongly associated with poorer survival after curative radiotherapy.
Twice-daily radiotherapy was associated with longer survival in younger limited-stage small cell lung cancer
Among patients under 70, twice-daily chemoradiotherapy was associated with 36.0 versus 22.2 months median survival, without higher acute toxicity.
Radiotherapy benefit and side-effect expectations were largely independent before treatment
Patients generally expected high radiotherapy benefit, but expectations of benefit and adverse events were not significantly correlated.
THUNDER-2 used early tumor regression to guide adaptive rectal cancer dose escalation
ERI-guided escalation to 60.1 Gy produced a 21.9% complete response rate in patients predicted to respond poorly.
Daily adaptation supported 17-fraction definitive chemoradiotherapy for cervical cancer
Daily online adaptation improved pelvic target coverage during 17-fraction cervical chemoradiotherapy, with 10% grade ≥3 gastrointestinal toxicity.
Diaphragm motion was less reliable than fiducials for markerless tumor tracking
Tumor–diaphragm geometry varied by approximately 4.5 mm during breathing, substantially more than tumor–fiducial relationships.