Low incidental brain doses were not linked to early cognitive decline after head and neck radiotherapy
Regional brain dose showed no significant association with cognition through 12 months, although only 24 patients completed one-year testing.
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Extratumoral perineural invasion predicted worse outcomes after postoperative oral cavity radiotherapy
Extratumoral perineural invasion predicted poorer survival, while microscopic versus macroscopic extranodal extension did not meaningfully separate outcomes.
Generative AI is spreading across radiation therapy workflows, but validation remains the bottleneck
A scoping review maps generative AI across imaging, documentation, QA and decision support while emphasizing major safety and governance gaps.
Deep learning reduced combined truncation and metal artifacts in half-detector CBCT
HD-TMAR improved metal-region PSNR from 25.5 to 35.5 dB in simulated half-detector CBCT while preserving dental anatomy.
Rectal spacer geometry remained stable throughout five-fraction prostate SBRT
Hydrogel spacers showed no meaningful loss of geometry during prostate SBRT, supporting stable rectal separation across the treatment course.
MR-only CyberKnife planning achieved near-equivalent dosimetry for brain metastases
Synthetic CT reproduced CyberKnife target dosimetry closely and enabled submillimetre translational image guidance, although rotational errors were more variable.
Task-specific deep learning reduced CT metal artifacts in cervical brachytherapy
Task-specific deep learning halved pelvic artifact burden, improved applicator reconstruction to 0.1 mm, and shortened organ contouring by up to 40%.
Three clinical variables predicted moderate-to-severe esophagitis during esophageal cancer radiotherapy
Tumor location, hypertension and albumin predicted moderate-to-severe acute esophagitis with an internally validated AUC of 0.816.
FLASH and conventional irradiation triggered similar mitochondrial remodeling in head and neck cancer cells
Both dose rates increased mitochondrial respiration after irradiation, with no clear FLASH-specific mitochondrial phenotype under normoxic conditions.
Automated proton planning reproduced clinical head and neck NTCP estimates within minutes
Automated proton plans reproduced clinical dysphagia and xerostomia estimates closely while reducing optimization time from days to about one hour.
Bullous pemphigoid developed during breast radiotherapy with concurrent pembrolizumab
Bullous pemphigoid emerged after seven radiotherapy fractions during pembrolizumab, spreading beyond the treatment field and ultimately preventing completion of both therapies.
SUPREMO radiotherapy modestly worsened chest wall symptoms without broader quality-of-life loss
EXCERPT At five years, chest wall radiotherapy modestly worsened local symptoms but did not significantly affect overall quality of life or major functional domains.
Prostate target expansion identified fractions most likely to benefit from online re-optimization
Without online re-optimization, 65.3% of prostate fractions missed 95% target coverage, with later target expansion strongly linked to coverage loss.
More than half of surveyed radiation oncology professionals considered leaving their position
Intent to leave was reported by 51.7%, with team culture, wellbeing and career development independently associated with retention.
Ultra-high dose-rate proton DNA damage changed with scavenger concentration and dose
Ultra-high dose-rate protons produced fewer DNA breaks at low scavenger concentration, but the effect diminished or reversed under other experimental conditions.