Bladder-only radiotherapy substantially irradiated adjacent pelvic nodes regardless of IMRT technique
Obturator nodes received about 75% of the prescribed bladder dose incidentally, with similar regional exposure from VMAT and fixed-field IMRT.
Latest research
Search the archiveCT-based cervical brachytherapy achieved 84% five-year local control
Routine CT-based adaptive brachytherapy achieved 84.4% five-year local control despite 56.9% of patients having stage III–IV cervical cancer.
Twenty-fraction head and neck radiotherapy was feasible in older and comorbid patients
Ninety-five percent completed 55 Gy in 20 fractions, with encouraging outcomes in early p16-positive oropharyngeal cancer despite substantial acute toxicity.
Updated AI auto-contouring cut rectal contouring time by 59%
Second-generation AI reduced rectal radiotherapy contouring time from 41 to 17 minutes while improving accuracy and consistency.
Environ SRS mask reduced attenuation and vertical setup variability versus Encompass
Environ showed less static-beam attenuation and lower vertical setup variability than Encompass while maintaining accurate HyperArc dose calculation.
Uncertainty estimates flagged neural-network dose modelling failures in MR-guided radiotherapy
Calibrated uncertainty thresholds kept gamma-defined dose-modelling failure below 10% while accepting 45–77% of irradiation segments.
Multimodal deep-learning toxicity models remain unready for routine head and neck radiotherapy
Ten contemporary multimodal deep-learning studies showed inconsistent external performance, calibration and reporting, limiting clinical use of personalized toxicity prediction.
Definitive pelvic radiotherapy was associated with longer survival in stage IVB cervical cancer
Median survival was 25 versus 18 months with chemotherapy plus definitive pelvic radiotherapy after propensity matching in stage IVB cervical cancer.
Daily MR-guided salvage radiotherapy showed low severe toxicity after prostatectomy
Daily adaptive salvage radiotherapy produced 6% new grade ≥2 urinary toxicity at 12 months in a prospective 51-patient cohort.
Non-invasive ventilation markedly reduced abdominal organ motion during MRI
Mechanical ventilation reduced median liver motion from 29 mm during free breathing to 9 mm at 60 breaths per minute with PEEP.
Aperture-restricted VMAT substantially reduced heart dose during left-sided regional nodal irradiation
Restricting deep VMAT apertures reduced heart and ipsilateral lung exposure across three linacs while maintaining comprehensive breast and nodal coverage.
Reduced-volume MR-guided RT was feasible in glottic cancer, with two recurrences
Reduced-volume MR-guided RT caused no grade ≥3 toxicity, but two of ten patients developed in-field recurrence after five-fraction treatment.
FLASH proton therapy preserved ocular function without reducing short-term tumor control
FLASH protons largely preserved ocular structure and retinal function after 24 Gy while maintaining short-term tumor control in mice.
Hypofractionated salvage radiotherapy did not improve biochemical control after prostatectomy
Four-year biochemical control was similar with 65 Gy in 26 fractions and 66 Gy in 33 fractions, while gastrointestinal toxicity was higher.
Breath-hold proton therapy was clinically feasible for mediastinal lymphoma
Across 187 fractions, surface-guided breath-hold IMPT remained highly stable, with only one patient requiring adaptive replanning.