Oral copper chelation preserved salivary gland function after irradiation in mice
Systemic tetrathiomolybdate reduced collagen deposition and preserved saliva secretion after irradiation of mouse submandibular glands.
Latest
ESTRO defined minimum standards for prostate SBRT implementation
ESTRO recommends prostate SBRT for selected intermediate-risk disease with MRI-based contouring, rigorous quality assurance, and daily image guidance.
Immune-sparing lung SBRT planning reduced lymphocyte loss in a randomized phase II trial
Optimizing dose to blood- and immune-rich structures reduced lymphocyte depletion and prevented grade 3 lymphopenia after early-stage lung SBRT.
Modelled actinium-225 delivery reduced glioblastoma clonogens but had limited spatial reach
Convection-enhanced actinium-225 markedly reduced modelled clonogenic survival, but effective coverage extended only about 1.4 cm from each catheter.
Probabilistic coronary habitats enabled artery-focused cardiac sparing without angiography
Automatically predicted coronary habitats captured most arteries and enabled substantial dose reductions in three retrospectively replanned thoracic cases.
GPU dose engine calculated MRI-guided proton plans within 14 seconds
gPRIDE closely matched Monte Carlo calculations for most anatomies and completed MRI-guided proton dose calculations within 13.7 seconds.
Gold nanoparticles increased proton radiosensitivity without a clear size-dependent effect
Gold nanoparticles increased proton-induced clonogenic killing from 4 Gy onward, with similar sensitization using 20- and 50-nm particles.
Five-fraction prostate SBRT showed low severe toxicity across Austrian centres
Linac-based 40 Gy in five fractions produced low severe toxicity and rapid urinary recovery across seven centres, although follow-up remained short.
Photon robust optimization remains technically promising but poorly standardized
Robust photon planning usually improved uncertainty-resistant target coverage, but modelling, evaluation, and reporting varied substantially across the literature.
Vaginal D2cc predicted late toxicity after EBRT plus cuff brachytherapy
Higher vaginal D2cc and target-dose distribution independently predicted grade 1–2 vaginal toxicity after combined external-beam radiotherapy and cuff brachytherapy.
First on-treatment CBCT best predicted lung radiotherapy response in a small cohort
Adding the first treatment CBCT improved response and survival prediction, while additional scans progressively reduced classification performance.
Surface guidance matched skin marks for breast setup and reduced positioning variability
Single-camera surface guidance provided comparable mean setup accuracy with less variability, while intrafraction breast motion remained below 3 mm in most observations.
Simple phantoms increased students’ reported understanding of radiation medicine
Low-cost diagnostic and treatment phantoms improved students’ self-reported understanding of radiation medicine, although formal learning outcomes were not assessed.
RadComp protons lowered mean cardiac dose without improving early cardiac-related quality of life
Protons substantially reduced mean cardiac exposure, but no cardiac dose metric predicted patient-reported symptoms during the first six months.
Most PLATO quality-of-life deficits recovered by six months, but advanced disease remained burdensome
Most treatment-related deficits improved by six months, although bowel and sexual problems persisted in several standard-dose and locally advanced groups.