Immunotherapy-based TNT eliminated nodal disease in ypT0–1 rectal tumours
No positive lymph nodes were found in ypT0–1 tumours after immunotherapy-based TNT, supporting further study of local excision.
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ECHO automated lung planning across seven fractionation schedules in routine practice
ECHO generated consistent lung IMRT and VMAT plans while reducing active planner time by approximately 90 minutes per case.
Three-week locoregional breast radiotherapy was noninferior for arm lymphedema
40 Gy in 15 fractions did not increase three-year arm lymphedema or compromise recurrence and mortality outcomes compared with 50 Gy.
Oxaliplatin-based total neoadjuvant therapy improved three-year DFS in high-risk rectal cancer
Doublet total neoadjuvant therapy improved three-year disease-free survival, metastasis-free survival, and pathological complete response compared with conventional chemoradiotherapy.
AutoAdapt produced acceptable prostate MR-guided plans with minimal planner input
AI-generated constraints produced clinically acceptable adaptive prostate plans, although only seven of ten met every prespecified planning objective.
PocketNet matched nnU-Net segmentation with 40-fold lower model storage
PocketNet matched nnU-Net accuracy for cervical MRI segmentation while using 40-fold less storage and approximately half the training time.
Prostate focal boost review defines MRI-based contouring and isotoxic planning
MRI-defined biopsy-confirmed lesions can be boosted safely when robust image guidance and normal-tissue constraints take priority over complete boost coverage.
CyberKnife dose models found size-dependent but non-monotonic brain metastasis control
Tumour-size strata showed non-monotonic BED–control relationships, while machine-learning performance remained unvalidated outside a single retrospective centre.
A 55-gene hypoxia signature identified poor-prognosis cervical cancer across cohorts
A 55-gene hypoxia classifier independently predicted worse survival and retained prognostic value across Manchester, Seoul, and Norwegian cervical cancer cohorts.
Breast brachytherapy review defines practical standards for APBI delivery
Successful breast brachytherapy depends on careful patient selection, suitable cavity anatomy, sound implant geometry, accurate reconstruction, and rigorous treatment QA.
Iodine-125 brachytherapy achieved short-term control in previously irradiated cervical nodal metastases
Iodine-125 seed implantation produced 90% three-month disease control, but median local progression-free survival was nine months.
Different factors predicted cardiac-event subtypes after hypofractionated breast radiotherapy
Planning-CT calcification and age predicted atherosclerotic events, while anthracyclines and respiratory toxicity predicted other cardiac complications.
Higher pretreatment LMR weakly predicted cervical tumour shrinkage after EBRT
Pretreatment lymphocyte-to-monocyte ratio was independently associated with cervical tumour shrinkage, but its standalone discrimination was poor.
Exit-dose gamma alerts identified head-and-neck replanning needs on Halcyon-E
Strict exit-dose gamma thresholds correlated with anatomical change and identified all clinically replanned patients in a retrospective validation cohort.
Reinforcement learning adapted proton spot delivery across respiratory phases
Patient-specific reinforcement learning improved moving-target coverage over static GTV plans while reducing some normal-tissue exposure compared with ITV planning.