Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction has the strongest evidence, while proton therapy and immunotherapy-based de-escalation remain less established.
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HyperSight protocol selection substantially changed CBCT organ dose
Low Dose HyperSight protocols reduced exposure by 55%, while Slow and Large protocols increased imaging dose and accentuated secondary-risk estimates.
FLASH reduced corneal injury after whole-brain irradiation in mice
FLASH preserved corneal thickness and collagen organization better than conventional irradiation at 10 and 15 Gy, but protection weakened at 20 Gy.
Skin microbiome signatures were associated with moderate-to-severe breast radiodermatitis
Clostridium, Anaerococcus US436 and Granulicatella elegans were associated with moderate-to-severe acute dermatitis during breast radiotherapy.
Five-fraction prostate radiotherapy reduced estimated carbon emissions by 59%
Five-fraction prostate radiotherapy produced 58.6% lower estimated carbon emissions than a 26-fraction schedule, mainly by reducing patient travel.
Review maps three strategies to reduce toxicity in nasopharyngeal carcinoma
Response-guided target reduction and sequential chemoradiotherapy have the strongest evidence, while proton and immunotherapy-based approaches remain less established.
Five-fraction whole-breast irradiation showed low short-term toxicity across 28 Italian centres
Whole-breast irradiation with 26 Gy in five fractions produced mainly grade 1 toxicity in 2,036 patients, including those receiving a boost.
Two-fraction HDR brachytherapy achieved durable control in favourable-risk prostate cancer
High-dose-rate brachytherapy using 13.5 Gy twice achieved 81.6% ten-year biochemical control with limited late genitourinary toxicity.
Small gastrointestinal PRV margins limited dose increases but did not encompass pancreatic SABR motion
Two- to five-millimetre gastrointestinal margins usually limited delivered dose increases but frequently failed to encompass interfraction organ motion.
Robust IMPT modestly reduced organ-at-risk dose in five-fraction prostate proton therapy
SFUD and robust IMPT maintained target coverage under uncertainty, while IMPT modestly reduced rectal and bladder dose.
Pulsed photon reirradiation showed 27-month median progression-free survival in recurrent meningioma
Temporally modulated pulsed radiotherapy achieved a median progression-free survival of 27.2 months in large, previously irradiated recurrent meningiomas.
Postoperative radiotherapy did not improve survival beyond chemotherapy in pT3N0M0 oesophageal cancer
Adding postoperative radiotherapy to chemotherapy did not significantly improve survival after R0 resection of pT3N0M0 oesophageal squamous cell carcinoma.
Dose-escalated chemoradiotherapy improved nine-year survival in locally advanced rectal cancer
A 56 Gy simultaneous integrated boost improved nine-year survival and disease control compared with standard 50 Gy chemoradiotherapy.
GPT-4.1 retrieved TrueBeam troubleshooting history but retained safety risks
A retrieval-augmented GPT-4.1 chatbot rapidly surfaced previous TrueBeam faults, but procedural, role-definition and safety errors remained.
Consolidative and salvage primary-tumour SABR showed similar outcomes in stage IV NSCLC
Primary-tumour SABR before progression or at oligoprogression produced similar survival and pneumonitis rates in selected patients with stage IV NSCLC.