Review links chemoresistance and radioresistance through shared adaptive programmes
Chemotherapy and radiotherapy resistance may converge on shared DNA-repair, redox, metabolic, stemness and microenvironmental adaptations.
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Interpretable autoencoder detected anomalous IMRT plans with high discrimination
An autoencoder identified anomalous IMRT plans with an area under the curve of 0.98 and explained which parameters drove each alert.
Single-fraction lung brachytherapy produced progressive consolidation and fibrotic retraction
Pulmonary consolidation was common after single-fraction interstitial brachytherapy and frequently evolved into progressive retraction during the second year.
ABS defines competencies for endobronchial and esophageal brachytherapy training
The American Brachytherapy Society outlines clinical, procedural, planning and safety competencies for trainees performing endobronchial and esophageal brachytherapy.
In-beam PET enabled real-time radioactive ion beam range adaptation in mice
Radioactive carbon-11 beams enabled PET-guided range adjustment during irradiation, with biological outcomes matching insufficient, optimal and excessive beam penetration.
Prostate reirradiation strategies remain heterogeneous despite encouraging prospective outcomes
Prospective prostate reirradiation studies reported generally acceptable toxicity, but target volumes, dose schedules and organ constraints varied substantially.
MRI deep learning identified oral tongue cancers associated with postoperative radiotherapy benefit
An MRI and pathology-based model identified a poor-risk oral tongue cancer group in which postoperative radiotherapy was associated with improved survival.
ATR inhibition enhanced cytotoxic and immunogenic radiation effects in pancreatic cancer cells
ATR inhibition increased radiation-induced cell killing and inflammatory signalling in KRAS wild-type pancreatic cancer cells, with weaker immunogenic effects in KRAS-mutated cells.
Carbon ions triggered distinct cell-cycle and chromatin transcriptional responses
At equal physical dose, carbon ions produced transcriptional changes distinct from X-rays, including stronger suppression of mitotic and chromatin-regulatory programmes.
Brain metastasis contouring variability depended on lesion and MRI factors
Brain metastasis contours showed generally high agreement, although lesion volume, oedema and magnetic resonance imaging field strength influenced variability.
Dose reporting mode affected spine SBRT audit results
A national end-to-end audit found acceptable spine stereotactic radiotherapy accuracy but systematic differences between dose-reporting conventions.
High geometric agreement did not guarantee physician acceptance of AI contours
Thoracic AI contours showed strong geometric and dosimetric agreement, but physicians still rejected some heart and oesophageal contours.
Deep learning reconstructed one-minute gated CBCT for pancreatic radiotherapy
Deep-learning reconstruction produced pancreatic gated cone-beam computed tomography comparable with conventional imaging while reducing estimated acquisition time and imaging dose.
DCAF4 promoted hepatocellular carcinoma resistance to iodine-125 brachytherapy
DCAF4 activated NRF2-dependent antioxidant defence and protected hepatocellular carcinoma against iodine-125 brachytherapy in preclinical models.
T1 relaxation mapping identified complete rectal cancer response at six weeks
Quantitative T1 relaxation time distinguished complete from incomplete rectal cancer response six weeks after neoadjuvant treatment with an area under the curve of 0.94.