Off-axis beam optimization reduced lung dose in posterior lung stereotactic body radiotherapy
Off-axis beam optimization preserved target coverage while reducing lung dose and enabling collision-free beam geometry for posterior lung lesions.
Latest
Oxygen ions produced greater pancreatic cancer cell killing than carbon ions and photons
Oxygen-ion irradiation showed higher biological effectiveness and more persistent DNA damage than carbon ions or photons in pancreatic cancer cells.
Split inhale–exhale planning reduced rib dose in lung stereotactic body radiotherapy
Splitting eight fractions between inhale and exhale breath-holds reduced maximum rib dose from 67.9 to 33.5 Gy without compromising target coverage.
Robust optimization reduced organ doses in long-course lung radiotherapy
Robust optimization preserved target coverage while reducing lung, heart, esophageal, spinal cord, and estimated immune-cell dose during long-course lung radiotherapy.
Failure analysis identifies target definition and motion management as key risks in stereotactic arrhythmia radioablation
Multimodal registration, motion management, and arrhythmia substrate definition were the highest-risk steps in stereotactic arrhythmia radioablation.
High-dose left anterior descending artery exposure was associated with cardiac events after breast radiotherapy
A 40 Gy equivalent dose to at least 18% of the left anterior descending artery was associated with more than twofold risk of cardiac events.
Neural model compresses proton Monte Carlo phase-space data while preserving dose accuracy
The neural model reduced phase-space storage from 3 gigabytes to 600 kilobytes while maintaining at least 89.9% gamma passing at 1%/1 mm.
No isolated failures in omitted nodal regions with reduced elective irradiation for early oropharyngeal cancer
Definitive intensity-modulated radiotherapy alone achieved 93.0% three-year overall survival, with no recurrence solely within omitted prophylactic nodal regions.
Large language model framework extracted cardiac events with up to 85.5% accuracy
The framework achieved 85.5% external-validation accuracy and reduced estimated review time from 822 hours to 2.3–4.8 hours.
Weekly cisplatin remained non-inferior in postoperative head and neck chemoradiotherapy
Weekly cisplatin remained non-inferior to three-weekly cisplatin at five years in postoperative high-risk head and neck chemoradiotherapy.
Tissue heterogeneity substantially alters absorbed dose in intraoperative radiotherapy
Absorbed dose near the applicator varied markedly by tissue composition despite accurate Monte Carlo calculation by the treatment planning system.
Mid-treatment tumour shrinkage predicted survival in oropharyngeal cancer
Tumour volume reduction above 40% during radiotherapy was independently associated with improved overall survival in patients with oropharyngeal cancer.
Preoperative radiotherapy did not worsen renal function after retroperitoneal sarcoma surgery
Preoperative radiotherapy was not associated with greater renal dysfunction after nephrectomy for retroperitoneal sarcoma during follow-up extending to 80 months.
ESTRO–ASTRO guidance standardises reirradiation for locally recurrent rectal cancer
ESTRO–ASTRO guidance supports selected rectal cancer reirradiation using 30–40 Gy regimens, cumulative dose assessment, inverse planning and daily volumetric imaging.
Early diffusion changes precede brain lesions after proton therapy for low-grade glioma
Regional diffusion changes distinguished patients who developed contrast-enhancing brain lesions as early as six months after proton therapy.