Longer interval to surgery predicted response after preoperative SBRT for luminal breast cancer
Preoperative SBRT produced a pooled 21.4% pathological complete response rate, with irradiation-to-surgery interval strongly associated with response.
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Complex deformable dose accumulation rarely changed adaptive SBRT decisions
More accurate deformable registration lowered estimated bowel dose, but produced nearly identical in-treatment adaptation decisions to simple DVH summation.
LET-optimized proton arc planning more than doubled the lattice peak-to-valley dose ratio
PATLESL increased lattice peak-to-valley dose ratio from 16.9 to 41.9 while reducing spot number and delivery time.
Beam-deflection compensation restored proton dose delivery inside an in-beam MR scanner
Energy-layer-wise compensation restored millimetre-level proton targeting despite magnetic-field beam shifts approaching 30 mm in an MR-integrated prototype.
DNA-PK and ATM inhibition strongly radiosensitized uveal melanoma models to proton therapy
Blocking DNA double-strand-break repair enhanced proton response across seven uveal melanoma spheroid models, with DNA-PK inhibition showing the strongest effect.
Reducing tomotherapy modulation beyond the gantry plateau saved almost no treatment time
The pre-plateau modulation factor preserved plan quality while further reduction created idle delivery time without meaningful efficiency gain.
3D-printed oral stents were associated with less toxicity after nasopharyngeal radiotherapy
Patient-specific stents improved tongue and parotid stability and were associated with substantially less hearing loss, dysphagia and dysgeusia.
Prophylactic dexamethasone reduced pain flare after radiotherapy for bone metastases
Across six randomized studies, prophylactic corticosteroids reduced radiation-induced pain-flare risk by 37%, although regimens and safety reporting varied.
Metformin reshaped glioblastoma immunity and improved radiotherapy response in mice
Metformin plus radiotherapy prolonged survival in two syngeneic glioblastoma models while shifting macrophage and T-cell populations toward antitumor phenotypes.
Simulation-free vaginal brachytherapy produced low five-year recurrence in high-intermediate-risk endometrial cancer
Five-year vaginal recurrence was 3.6% without verification imaging, versus 1.6% reported in the separate PORTEC-4a brachytherapy cohort.
Low-dose brain exposure diverged sharply between SRT platforms as metastasis number increased
CyberKnife best contained low-dose spread at high lesion burdens but required substantially longer treatment than faster VMAT strategies.
Anatomy-based traffic lights missed important dose changes during lung radiotherapy
In 604 fractions, traffic-light alerts partially identified target undercoverage but were unreliable proxies for organ-at-risk dose changes.
S100A8/A9 blockade improved survival after abdominal irradiation in mice
Paquinimod blockade of S100A8/A9 improved survival, intestinal regeneration and barrier recovery after abdominal irradiation in preclinical models.
International survey identifies culture and leadership as central radiation oncology retention drivers
Across 53 countries, workforce retention was shaped by culture, leadership, career development, resource strain, recognition and burnout.
Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.