Proton breast radiotherapy caused more acute dermatitis than photons in randomized DBCG substudy
Grade 2–3 dermatitis reached 71% with protons versus 20% with photons, but resolved within weeks and other acute toxicity was similar.
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PTCOG review maps emerging roles for particle therapy in gynecologic cancers
Carbon ions show the strongest signal in radioresistant gynecologic tumors, while proton evidence centers on adjuvant treatment and reirradiation.
Minibeam radiotherapy achieved 92% one-year local control in refractory superficial tumors
In the first clinical minibeam series, 86% had symptomatic improvement and one-year local control reached 92% with minibeam treatment alone.
Progesterone exposure was associated with visual deficits in women with meningioma
Unopposed progesterone use was associated with eightfold higher odds of tumor-related visual deficit among women referred for meningioma radiotherapy.
No tested head phantom fully met cranial synthetic CT QA criteria
Skull-equivalent anatomy improved synthetic CT performance, but none of ten tested head phantoms satisfied all geometric, HU and dosimetric criteria.
SMART planning reduced memory-circuit dose during SRS for ≥10 brain metastases
SMART reduced mean memory-circuit dose from 2.9 to 1.8 Gy while maintaining greater than 95% target coverage.
Esophageal radiosensitization has many molecular targets but little practice-ready clinical evidence
A broad 6R-based review identifies numerous radiosensitization targets, but most remain preclinical and evidence is heavily concentrated in squamous-cell carcinoma.
Treatment satisfaction remained 85% at ten years after prostate LDR brachytherapy
At ten years after prostate LDR brachytherapy, 85% of respondents remained satisfied, while bowel quality of life remained independently associated with satisfaction.
Brain metastasis SRS fractionation varied widely across Turkish radiation oncologists
Tumor volume and OAR proximity drove brain metastasis fractionation, while preoperative SRS showed a substantial preference-to-practice gap.
DWI/ADC changed residual cervical tumor geometry before brachytherapy despite similar overall volumes
Adding DWI/ADC produced substantially different residual GTV geometry before cervical brachytherapy, with a median Dice overlap of only 0.33.
Patients with documented fatigue were less likely to complete electronic symptom surveys after breast RT
Patients with clinician-documented fatigue had 39% lower odds of completing electronic fatigue assessments, exposing an important limitation of PRO-only monitoring.
Action-priority FMEA narrowed radiation therapy QA risks from 30 to seven
A severity-weighted action-priority framework identified the same seven highest RT workflow risks while avoiding 23 additional traditional FMEA flags.
OPT-former enabled near-real-time automated eye tracking during ocular proton therapy
OPT-former matched a three-network segmentation pipeline while processing eye images 2.6 times faster and improved further with patient-specific fine-tuning.
AI is moving across particle therapy planning but clinical validation remains the bottleneck
AI can automate particle planning, dose prediction, adaptation and quality assurance, but limited data and validation still constrain clinical adoption.
uTPS produced deliverable Halcyon VMAT plans comparable with Eclipse
uTPS generated Halcyon VMAT plans with generally comparable dosimetry to Eclipse and greater than 97% gamma passing rates.