Body composition adds little to radiotherapy toxicity prediction
Computed tomography-derived muscle measures ranked highly for toxicity and quality of life, but added little predictive value beyond established clinical factors.
Latest
Medical debt after radiotherapy linked to insurance and neighborhood disadvantage
Commercial insurance, current smoking, single status, and neighborhood disadvantage were independently associated with radiotherapy-related debt sent to collections.
End-to-end test achieved high dosimetric agreement across adaptive platforms
A reusable phantom-based test verified simulation-omitted adaptive workflows on cone-beam computed tomography-guided and magnetic resonance-guided treatment systems.
Induction chemotherapy benefit varied by cervical cancer risk and treatment density
Induction chemotherapy showed no overall survival benefit, with outcomes differing by disease risk and the intensity of pre-radiotherapy treatment.
Combined dose and linear energy transfer predict local control after carbon-ion radiotherapy
High-dose, high-linear-energy-transfer target coverage stratified local control after carbon-ion radiotherapy for adenoid cystic carcinoma.
Radiotherapy primes PDL1-targeted radionuclide therapy but splenic uptake limits efficacy
Radiotherapy increased tumor uptake of PDL1-targeted radionuclide therapy, while antibody co-dosing reduced splenic trapping and restored antitumor efficacy in mice.
Convergent 60 keV photons show cell-dependent biological effectiveness
Convergent 60 keV photons matched orthovoltage radiation and showed comparable or greater biological effectiveness than 6 MV photons, depending on cell type.
CyberKnife reduced low-dose exposure in left-sided partial-breast irradiation
CyberKnife improved conformity and reduced cardiac, pulmonary, and low-dose exposure, while noncoplanar linac techniques remained clinically acceptable alternatives.
Cosmesis reporting after radiotherapy for non-melanoma skin cancer remains inconsistent
Most studies used heterogeneous, poorly reproducible cosmetic assessment methods, limiting comparisons between radiotherapy techniques and supporting development of a validated standard.
Knowledge-based prostate planning transfers across fractionation regimens with comparable plan quality
A conventional-fractionation model produced clinically acceptable moderately hypofractionated prostate plans, with comparable overall quality and slightly reduced target homogeneity.
Commercial lung phantom density errors can reduce target coverage by 3%
Lot-to-lot density variation in lung-equivalent inserts reduced planning target volume coverage by up to 3%, exceeding the stated clinical tolerance.
Low monitor unit deliveries show pulse-limited variability on a modern linear accelerator
Discrete pulse counts limited fractional monitor unit precision, particularly for high-dose-per-pulse flattening filter-free beams.
Ultrahigh dose-rate protons reduce hydrogen peroxide yield in water
Hydrogen peroxide production decreased as proton dose rate increased, with Geant4-DNA simulations reproducing the oxygen-dependent experimental trend.
Monocular surface imaging enables real-time breast dose reconstruction
Patient-specific surface imaging reconstructed breast radiotherapy dose with a 93.8% gamma passing rate and 42-millisecond latency without additional imaging radiation.
Reference beam data may streamline commissioning but cannot replace local validation
Reference datasets can support linear accelerator beam modelling, but machine-specific measurements remain essential for small fields, complex delivery, and long-term verification.