Robust IMPT modestly reduced organ-at-risk dose in five-fraction prostate proton therapy
SFUD and robust IMPT maintained target coverage under uncertainty, while IMPT modestly reduced rectal and bladder dose.
Latest research
Search the archivePulsed photon reirradiation showed 27-month median progression-free survival in recurrent meningioma
Temporally modulated pulsed radiotherapy achieved a median progression-free survival of 27.2 months in large, previously irradiated recurrent meningiomas.
Postoperative radiotherapy did not improve survival beyond chemotherapy in pT3N0M0 oesophageal cancer
Adding postoperative radiotherapy to chemotherapy did not significantly improve survival after R0 resection of pT3N0M0 oesophageal squamous cell carcinoma.
Dose-escalated chemoradiotherapy improved nine-year survival in locally advanced rectal cancer
A 56 Gy simultaneous integrated boost improved nine-year survival and disease control compared with standard 50 Gy chemoradiotherapy.
GPT-4.1 retrieved TrueBeam troubleshooting history but retained safety risks
A retrieval-augmented GPT-4.1 chatbot rapidly surfaced previous TrueBeam faults, but procedural, role-definition and safety errors remained.
Consolidative and salvage primary-tumour SABR showed similar outcomes in stage IV NSCLC
Primary-tumour SABR before progression or at oligoprogression produced similar survival and pneumonitis rates in selected patients with stage IV NSCLC.
Review links chemoresistance and radioresistance through shared adaptive programmes
Chemotherapy and radiotherapy resistance may converge on shared DNA-repair, redox, metabolic, stemness and microenvironmental adaptations.
Interpretable autoencoder detected anomalous IMRT plans with high discrimination
An autoencoder identified anomalous IMRT plans with an area under the curve of 0.98 and explained which parameters drove each alert.
Single-fraction lung brachytherapy produced progressive consolidation and fibrotic retraction
Pulmonary consolidation was common after single-fraction interstitial brachytherapy and frequently evolved into progressive retraction during the second year.
ABS defines competencies for endobronchial and esophageal brachytherapy training
The American Brachytherapy Society outlines clinical, procedural, planning and safety competencies for trainees performing endobronchial and esophageal brachytherapy.
In-beam PET enabled real-time radioactive ion beam range adaptation in mice
Radioactive carbon-11 beams enabled PET-guided range adjustment during irradiation, with biological outcomes matching insufficient, optimal and excessive beam penetration.
Prostate reirradiation strategies remain heterogeneous despite encouraging prospective outcomes
Prospective prostate reirradiation studies reported generally acceptable toxicity, but target volumes, dose schedules and organ constraints varied substantially.
MRI deep learning identified oral tongue cancers associated with postoperative radiotherapy benefit
An MRI and pathology-based model identified a poor-risk oral tongue cancer group in which postoperative radiotherapy was associated with improved survival.
ATR inhibition enhanced cytotoxic and immunogenic radiation effects in pancreatic cancer cells
ATR inhibition increased radiation-induced cell killing and inflammatory signalling in KRAS wild-type pancreatic cancer cells, with weaker immunogenic effects in KRAS-mutated cells.
Carbon ions triggered distinct cell-cycle and chromatin transcriptional responses
At equal physical dose, carbon ions produced transcriptional changes distinct from X-rays, including stronger suppression of mitotic and chromatin-regulatory programmes.