Brain metastasis contouring variability depended on lesion and MRI factors
Brain metastasis contours showed generally high agreement, although lesion volume, oedema and magnetic resonance imaging field strength influenced variability.
Latest research
Search the archiveDose reporting mode affected spine SBRT audit results
A national end-to-end audit found acceptable spine stereotactic radiotherapy accuracy but systematic differences between dose-reporting conventions.
High geometric agreement did not guarantee physician acceptance of AI contours
Thoracic AI contours showed strong geometric and dosimetric agreement, but physicians still rejected some heart and oesophageal contours.
Deep learning reconstructed one-minute gated CBCT for pancreatic radiotherapy
Deep-learning reconstruction produced pancreatic gated cone-beam computed tomography comparable with conventional imaging while reducing estimated acquisition time and imaging dose.
DCAF4 promoted hepatocellular carcinoma resistance to iodine-125 brachytherapy
DCAF4 activated NRF2-dependent antioxidant defence and protected hepatocellular carcinoma against iodine-125 brachytherapy in preclinical models.
T1 relaxation mapping identified complete rectal cancer response at six weeks
Quantitative T1 relaxation time distinguished complete from incomplete rectal cancer response six weeks after neoadjuvant treatment with an area under the curve of 0.94.
Low-dose radiotherapy produced durable benefit in refractory plantar fasciitis
Low-dose radiotherapy produced sustained pain, function and quality-of-life improvement after conservative treatment and shock-wave therapy had failed.
FLASH preserved mitochondrial function in non-tumorigenic pancreatic models
FLASH spared mitochondrial integrity in non-tumorigenic pancreatic models while producing tumour effects comparable with conventional-dose-rate irradiation.
SPPORT intensification did not worsen long-term quality of life
Short-term androgen deprivation impaired early sexual and hormonal quality of life, but treatment-arm differences were not clinically significant at five years.
Circadian disruption may modify radiation-induced acute myeloid leukaemia risk
Circadian dysregulation could impair DNA repair and haematopoietic control after radiation exposure, but direct evidence linking it to acute myeloid leukaemia is lacking.
Head and neck positioning management should extend beyond couch correction
Rigid couch correction cannot fully resolve regional posture mismatch, immobilization failure or progressive anatomical change during head and neck radiotherapy.
Late radiation necrosis after stereotactic radiosurgery temporally associated with COVID-19 vaccination
A case report describes pathology-confirmed late radiation necrosis after stereotactic radiosurgery, with radiographic progression temporally associated with repeated COVID-19 vaccination.
Review proposes harmonized reporting of biological dose across particle therapies
A translational review proposes shared reporting and quality-assurance principles for model-dependent biological dose in proton, carbon-ion and boron neutron capture therapy.
A 4.5 mm margin covered most intrafraction small-bowel motion during MR-guided radiotherapy
A 4.5 mm isotropic margin covered most observed small-bowel occupancy despite craniocaudal displacements exceeding 20 mm in some patients.
CT imaging features improved local and distant control prediction in nasopharyngeal carcinoma
Planning CT features added prognostic information for local and distant control but did not significantly improve overall or progression-free survival prediction.