Upright carbon ion plans matched supine dosimetry for prostate cancer
Upright carbon ion treatment plans achieved target coverage, organ sparing and simulated robustness comparable with conventional supine plans.
Latest research
Search the archiveMean lung dose strongly predicted pneumonitis after adjuvant breast radiotherapy
A mean lung dose threshold of 12.70 grays strongly separated patients who developed radiation pneumonitis after adjuvant breast radiotherapy.
Higher-dose iodine-125 brachytherapy was associated with longer survival in recurrent glioblastoma
Iodine-125 doses of 140–160 grays were associated with longer median survival than 120–140 grays in recurrent glioblastoma.
Smaller base-of-tongue volume was associated with prolonged feeding-tube dependence
Smaller base-of-tongue volume was associated with prolonged feeding-tube dependence after radiotherapy for oral cavity squamous cell carcinoma.
Automated framework linked 99.76% of radiotherapy planning and delivery datasets
The framework linked complete planning and delivery data for 13,871 plans with 99.76% success across two clinics.
FDG-PET-guided dose escalation did not improve control in advanced oropharyngeal and laryngopharyngeal cancers
Escalating metabolically active disease to 73.5 Gy did not improve locoregional control, disease-free survival, or overall survival versus 66 Gy.
Spine proton ablative radiotherapy achieved 74% two-year local control in selected patients
Spine proton ablative radiotherapy achieved 74% local control at one and two years, with no radiation myelopathy in a reirradiation-enriched cohort.
Medial retropharyngeal nodes were involved in 2.95% of non-endemic nasopharyngeal cancers
Medial retropharyngeal nodes were involved in 2.95% of German cases, but no recurrence occurred among patients whose elective volume omitted the region.
Particle therapy costing studies show major methodological heterogeneity
Only 12 eligible studies were found, with inconsistent methods and assumptions that limited meaningful comparison of particle therapy costs.
Fraction 15 was optimal for one-time offline replanning in head and neck proton therapy
A single offline replan at fraction 15 captured most achievable dosimetric benefit in simulated head and neck proton therapy.
MRI-guided prostate SBRT reduced low-dose exposure to sexual-function structures
MRI-guided SBRT with 2-mm margins reduced low- and intermediate-dose exposure of neurovascular bundles and pudendal arteries versus CT-guided treatment.
DEGRO supports ultrahypofractionation for localized prostate cancer but flags higher late urinary toxicity
DEGRO supports ultrahypofractionation for low- to intermediate-risk prostate cancer, with comparable control but increased late genitourinary toxicity in selected patients.
Intratumoral polyvinyl chloride was associated with radioresistance in hepatocellular carcinoma
PVC was detected in 37 of 72 HCC tumors and was associated with poorer response and progression-free survival after SBRT, immunotherapy, and bevacizumab.
Durvalumab improved 2-year progression-free survival after chemoradiotherapy in real-world stage III NSCLC
Consolidation durvalumab after concurrent chemoradiotherapy halved the adjusted risk of progression or death at two years in real-world stage III NSCLC.
Surface-contacted 3D bolus plus MLC reduced proton PBS lateral penumbra
Surface-contacted 3D boluses generally narrowed lateral penumbra and reduced surrounding dose versus a nozzle-mounted range shifter in proton PBS.