Five-fraction prostate and pelvic nodal SBRT showed low late toxicity
After prostate and pelvic nodal SBRT, no grade ≥3 late GU or GI toxicity occurred among 101 patients with high-risk disease.
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Search the archiveMultidisciplinary radiopharmaceutical dosimetry changed management in one-third of selected patients
In 19 high-risk patients receiving 177Lu-PSMA-617, post-cycle 1 dosimetry changed management in 32%, prompting five activity reductions and one delay.
Cardiac toxicity occurred in 8% after central and ultracentral lung SBRT
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
Lower microvascular health predicted acute radiotherapy toxicity across three cancer cohorts
Lower pretreatment microvascular health was associated with more acute toxicity overall, while disease-specific performance was strongest in breast cancer.
Lung SBRT studies use inconsistent definitions of local control
Nearly one-third of lung SBRT studies counted failures beyond the treated tumor as local events, limiting comparison of reported control rates.
FLASH attenuated inflammatory and pro-fibrotic lung transcription after irradiation
In mice, FLASH reduced acute chemokine and later macrophage-associated transcription versus conventional irradiation, without significantly reducing collagen deposition.
Postoperative radiotherapy provided better quality of life and value in oral cavity cancer
Postoperative conventional radiotherapy caused fewer head-and-neck symptoms and dominated preoperative accelerated radiotherapy in the five-year cost-utility analysis.
FDG-PET and multiparametric MRI did not reliably predict pCR in esophageal cancer
Combined FDG-PET and multiparametric MRI achieved only modest pCR prediction after neoadjuvant chemoradiotherapy, with a cross-validated AUC of 0.65.
Bidirectional GAN preserved CT numbers and dose accuracy in head-and-neck planning CT
BiHU-GAN generated synthetic contrast and non-contrast CT with high contour agreement and at least 95% gamma pass rates at 2%/2 mm.
Pelvis-inclusive SBRT reduced acute gastrointestinal toxicity in high-risk prostate cancer
Once-weekly prostate-and-pelvis SBRT reduced acute gastrointestinal toxicity versus conventional IMRT without significantly increasing genitourinary toxicity.
Higher CTV minimum dose predicts local control after separation surgery and spine SBRT
Higher postoperative CTV minimum BED10 was associated with lower local failure after separation surgery and spine SBRT.
RapidPlan lung SBRT model used gEUD objectives for reproducible planning
A RapidPlan lung SBRT model generated clinically acceptable plans in 52% of validation cases on first optimization.
Single-field optimization improved proton LATTICE motion robustness
Single-field optimization improved proton LATTICE motion robustness
Higher-BED palliative radiotherapy improved symptoms in rectal cancer
BED >37.5 Gy improved symptomatic control, while 6-month local control remained 46% in frail, elderly, or metastatic rectal cancer.
Carbon ion re-irradiation showed feasible salvage outcomes in recurrent pelvic sarcoma
High-dose carbon ion re-irradiation achieved 83.1% 3-year survival with no grade 4 toxicity in recurrent pelvic sarcoma.