Neutron background limits prompt-gamma range verification in carbon-ion therapy
Prompt-gamma profiles tracked beam range, but stronger neutron backgrounds reduced retrieval precision for carbon ions under clinically relevant conditions.
Latest
Machine-specific timing model improves synchrotron proton spot delivery prediction
Measured multi-energy extraction characteristics enabled accurate delivery-time prediction across 605 clinical proton fields, supporting more reliable interplay simulations.
Dose de-escalation improved patient-reported outcomes in early p16-positive oropharyngeal cancer
Reducing radiotherapy from 70 Gy to 60 Gy was associated with better one-year swallowing outcomes and lower acute toxicity in selected patients.
Prolonged pembrolizumab was associated with longer survival after chemoradiation in non-small cell lung cancer
Longer pembrolizumab exposure after chemoradiation was associated with lower mortality, but immortal time bias prevents causal interpretation.
Explainable machine learning predicts structure-specific quality assurance performance in intensity-modulated radiotherapy
Anatomy- and dose-based machine learning predicted gamma passing rates accurately for organs at risk, but less reliably for target volumes.
Single-fraction ultrahigh dose-rate proton therapy showed early safety in thoracic metastases
Single-fraction proton treatment produced pain responses without grade 2 or higher related toxicity in 10 patients with thoracic bone metastases.
Glutathione S-transferase mu 3 limits testicular injury after ultrahigh dose-rate irradiation
In mice, ultrahigh dose-rate X-rays caused less early testicular damage than conventional irradiation, with protection linked to ferroptosis suppression.
Ultrahigh dose-rate radiotherapy still requires conformal planning and conservative dose constraints
Normal-tissue sparing with ultrahigh dose-rate radiotherapy remains conditional and cannot replace conformal dosimetry, organ-at-risk constraints, or rigorous quality assurance.
Dual-scan conformal cone-beam computed tomography improves target-region image quality
Dynamic collimation improved target-region contrast and signal-to-noise ratio while preserving full-field information without increasing the total photon budget.
Vaginal cuff brachytherapy boost was associated with improved survival in stage II endometrial cancer
Adding vaginal cuff brachytherapy to whole pelvis radiation therapy was associated with improved overall survival in stage II endometrioid endometrial cancer.
Semi-automated needle planning shortens cervical brachytherapy workflow while preserving clinical coverage
Semi-automated trajectory planning reduced workflow time and needle use while maintaining clinically acceptable target coverage and organ-at-risk doses.
Risk-adapted esophagus sparing reduces dose with low severe esophagitis in lung cancer
Risk-adapted esophagus-sparing radiotherapy maintained target coverage, with grade 3 esophagitis in only 1.25% of high-risk patients.
Bone marrow-sparing radiotherapy lowers pelvic marrow dose without proven toxicity reduction
Bone marrow-sparing planning reduced pelvic marrow dose, but heterogeneous evidence did not confirm a consistent reduction in hematologic toxicity.
Patient-led genital positioning improved comfort and modesty during thigh sarcoma radiotherapy
A reusable positioning pouch displaced the genitalia from the treatment field while receiving high satisfaction ratings from patients and radiation therapists.
Four-dimensional prompt-gamma imaging detected proton range changes during pancreatic treatment
Four-dimensional prompt-gamma imaging detected clinically relevant proton range shifts associated with anatomical change during pancreatic proton therapy.