ALTJ V35Gy above 50% tripled lymphedema risk after breast radiotherapy
Irradiating more than half of the axillary-lateral thoracic junction to 35 Gy was independently associated with a threefold higher lymphedema risk.
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Dose–LET hotspots were associated with capsular contracture after proton postmastectomy radiotherapy
Combined high-dose and high-LET exposure around breast implants was associated with severe capsular contracture after proton postmastectomy radiotherapy.
OmicsMap improved CT-based distant metastasis prediction across head and neck cancer cohorts
Modeling relationships between CT radiomic features improved distant-metastasis prediction over conventional radiomics across independent head and neck cancer cohorts.
Multi-RBE LET optimization increased target LET by 29% in sacral chordoma
Multi-RBE carbon-ion optimization increased near-minimum GTV LET by 29.2% while maintaining conventional dose coverage and interfraction robustness.
Deep learning predicted distant metastasis from CT and dose in head and neck cancer
A model integrating planning CT, 3D dose and tumor contours achieved strong external prediction of distant metastasis but weaker local-recurrence performance.
Robust optimization minimized lung-dose trade-offs in carbon-ion planning for stage I NSCLC
Robust optimization improved target coverage with less lung-dose penalty than margin expansion, while density override was particularly useful for solid tumors.
Higher immune-cell radiation dose was associated with worse breast cancer-specific survival
Each 1-Gy increase in estimated immune-cell dose was associated with 66% higher breast cancer mortality after multivariable adjustment.
Nearly one-third of abdominal radiotherapy patients could not maintain planned DIBH
Despite successful simulation, 31.7% required DIBH gate modification or conversion to free breathing during abdominal radiotherapy.
Multimodal AI predicted radiation proctitis across different CT devices with 0.865 AUC
Combined radiomics, foundation-model and clinical features predicted grade ≥2 radiation proctitis with 0.865 AUC on an independent imaging device.
PTV coverage prescriptions poorly represented delivered tumor dose in lung SBRT
D95% and D98% PTV prescriptions produced substantial interpatient variability, while GTV- and ITV-based median or mean doses were more accurate.
Cervical cancer advanced by one stage approximately every 8.6 weeks before radiotherapy
Cervical cancer stage progression was estimated every 8.6 weeks of treatment delay and was faster among women living with HIV.
ASTRO survey maps different workforce pressures across US radiation oncology practice
Administrative burden and staffing concerns were widespread, while reimbursement dominated private-practice concerns and unstable research funding dominated physician-scientist concerns.
SBRT plus dual checkpoint blockade produced 72.7% six-month PFS in oligometastatic HNSCC
Durvalumab, tremelimumab and SBRT produced 72.7% six-month progression-free survival in 33 patients with oligometastatic HNSCC.
Decision aid supported DAHANCA 35 trial discussions when clinicians actively used it
A DAHANCA 35 patient decision aid was feasible and acceptable, but its value depended strongly on clinician introduction and engagement.
Deep learning generated CT-free PET with near-zero SUV bias in NSCLC
Emission-only PET synthesis produced 0.72% SUVmax bias and 99.2% contrast recovery in an independent NSCLC test cohort.