Single-fraction prostate radiotherapy achieved 92.9% three-year biochemical relapse-free survival
A single 19-Gy fraction achieved 92.9% three-year biochemical relapse-free survival with limited grade 2 gastrointestinal and genitourinary toxicity.
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Insufficient ferroptosis promoted regulatory T-cell accumulation and radiotherapy resistance
Radioresistant tumors showed impaired ferroptosis and regulatory T-cell accumulation, while sorafenib enhanced the response to irradiation in mice.
Concurrent chemotherapy improved progression-free but not overall survival in low-volume head and neck cancer
Concurrent chemotherapy improved progression-free survival without a significant overall survival benefit in early primary tumors with low-volume nodal disease.
Preoperative single-fraction and fractionated stereotactic radiotherapy showed similar outcomes after brain metastasis resection
Preoperative single-fraction and fractionated stereotactic radiotherapy produced similarly low composite event rates after resection of brain metastases.
FLASH radiotherapy reduced hepatic injury in a murine breast cancer model
FLASH radiotherapy preserved hepatic structure and metabolic homeostasis while maintaining tumor control in a preclinical breast cancer model.
Two-hour fasting did not reliably stabilize stomach volume during pancreatic stereotactic radiotherapy
Standardized two-hour fasting produced reproducible stomach volumes in only 42% of patients receiving magnetic resonance-guided pancreatic stereotactic radiotherapy.
Quality of life remains impaired after chemoradiotherapy for anal squamous cell carcinoma
Patients reported persistently worse quality of life and functioning approximately two years after chemoradiotherapy than matched individuals without cancer.
Brain radiotherapy alone did not deplete circulating lymphocytes in a prospective cohort
Circulating lymphocyte counts remained stable during brain radiotherapy without concurrent chemotherapy, consistent with low estimated blood and cervical lymph-node dose
Macro Monte Carlo accelerates very high energy electron dose calculation with high accuracy
A macro Monte Carlo framework reproduced reference dose calculations for very high energy electron beams up to 250 megaelectronvolts while improving computational efficiency by as much as twenty-sevenfold.
Hybrid foundation model produces expert-preferred brain metastasis contours
A hybrid foundation-model framework achieved 94% lesion-wise sensitivity and was preferred over physician-generated brain metastasis contours in blinded, bias-adjusted comparisons.
Skin-constrained intensity-modulated proton therapy matches photon postmastectomy radiotherapy for acute dermatitis
Skin-constrained intensity-modulated proton therapy produced acute dermatitis rates comparable with photon postmastectomy radiotherapy (grade ≥2: 47% vs 48%).
Proton reirradiation achieves high locoregional control in recurrent breast cancer
Pencil-beam proton reirradiation for locoregional breast cancer recurrence achieved 95% three-year overall survival, with severe toxicity uncommon despite a 21% rib-fracture rate.