Short-course radiotherapy may be a stronger immunotherapy partner in rectal cancer
Recent trials report 40–61% pathologic complete response with short-course radiotherapy plus immunotherapy, but mature comparative outcomes remain unavailable.
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Internal mammary node response may reveal occult disease in early breast cancer
Nearly 40% of visible internal mammary nodes regressed after chemotherapy, including 22% in patients without axillary nodal disease.
Cannabinoids reduced glioblastoma apoptosis after chemotherapy and radiation in vitro
Several cannabinoids reduced therapy-induced glioblastoma apoptosis and enhanced clonogenic survival in vitro, raising concern about concurrent use during treatment.
Radiotherapy was not associated with longer survival in breast cancer leptomeningeal disease
In 232 women with breast cancer leptomeningeal disease, radiotherapy was not associated with longer overall survival, while systemic therapy was.
Low CAVIN3 expression was associated with better radiotherapy response in cervical cancer
Low CAVIN3 expression was associated with higher treatment response and substantially longer progression-free survival after radiotherapy for cervical cancer.
Radiotherapy may offset the survival disadvantage of perineural invasion in cutaneous head and neck cancer
PNI-positive patients without radiotherapy had worse survival, while those receiving radiotherapy had outcomes comparable to patients without PNI.
Six-fraction chemoradiation worsened survival in newly diagnosed glioblastoma
Six-fraction chemoradiation shortened median survival from 21 to 13 months and substantially increased radiation necrosis compared with standard treatment.
Total neoadjuvant therapy is now central to high-risk rectal cancer and organ preservation
Total neoadjuvant therapy is now central to high-risk rectal cancer and organ preservation
Low incidental brain doses were not linked to early cognitive decline after head and neck radiotherapy
Regional brain dose showed no significant association with cognition through 12 months, although only 24 patients completed one-year testing.
Extratumoral perineural invasion predicted worse outcomes after postoperative oral cavity radiotherapy
Extratumoral perineural invasion predicted poorer survival, while microscopic versus macroscopic extranodal extension did not meaningfully separate outcomes.
Generative AI is spreading across radiation therapy workflows, but validation remains the bottleneck
A scoping review maps generative AI across imaging, documentation, QA and decision support while emphasizing major safety and governance gaps.
Deep learning reduced combined truncation and metal artifacts in half-detector CBCT
HD-TMAR improved metal-region PSNR from 25.5 to 35.5 dB in simulated half-detector CBCT while preserving dental anatomy.
Rectal spacer geometry remained stable throughout five-fraction prostate SBRT
Hydrogel spacers showed no meaningful loss of geometry during prostate SBRT, supporting stable rectal separation across the treatment course.
MR-only CyberKnife planning achieved near-equivalent dosimetry for brain metastases
Synthetic CT reproduced CyberKnife target dosimetry closely and enabled submillimetre translational image guidance, although rotational errors were more variable.
Task-specific deep learning reduced CT metal artifacts in cervical brachytherapy
Task-specific deep learning halved pelvic artifact burden, improved applicator reconstruction to 0.1 mm, and shortened organ contouring by up to 40%.