Modern neck radiotherapy was associated with better locoregional control in advanced thyroid cancer
In advanced differentiated thyroid cancer, IMRT/VMAT was associated with a 61% lower hazard of locoregional relapse or death.
Latest research
Search the archiveHigh-dose prednisone produced transient symptom improvement in radiation-associated lower cranial neuropathy
Prednisone 3 mg/kg improved symptoms in 3 of 5 survivors with late cranial neuropathy, but the benefit disappeared by 6–10 weeks.
Breast radiotherapy patients valued both animated video and printed education
Video and printed education performed similarly, while half of patients preferred video and self-reported anxiety fell from 30% to 5%.
Commercial AI contouring cut head and neck delineation workflow from 44 to 5 minutes
Three commercial AI models produced broadly usable head-and-neck contours, reducing review time to five minutes, but anatomical definitions differed importantly between vendors.
Biological dose calculations remain poorly standardized across radiotherapy practice
Clinicians applying dose-equivalence models to identical scenarios agreed only 25.8%, exposing major variability in treatment gaps, hypofractionation and reirradiation.
Upfront 54 Gy radiotherapy stopped growth of an inoperable cranial Masson’s tumor
In one rapidly enlarging cranial Masson’s tumor, 54 Gy in 27 fractions halted growth and enabled subsequent necrosectomy.
AI detected subtle temporal changes in routine prostate MR-Linac images
A deep-learning model ordered first-to-last fraction images with 95% accuracy, while smaller longitudinal changes were associated with later biochemical recurrence.
Focal lumbosacral plexus hotspots may contribute to severe toxicity after prostate radiotherapy
Two prostate RT cases suggest that focal lumbosacral plexus hotspots, particularly near 70 Gy, may contribute to severe neurologic toxicity.
BNCT achieved high response but limited local control in recurrent oral cancer re-irradiation
Accelerator-based BNCT produced an 80% response and 51.1% two-year survival, but two-year local control was 31.8% with substantial toxicity.
Endorectal balloon enabled 78 Gy salvage boost for prostate-bed recurrence
In one macroscopic recurrence abutting rectum, an endorectal balloon reduced rectal V75 from 24.6% to 8.6%, enabling a 78 Gy boost.
Online adaptation preserved kidney SABR coverage, but daily anatomical effects were small
Adaptation preserved prescription-level D99 in all 50 fractions, while a 1-mm margin achieved 98% despite minimal daily dose perturbation.
TIMELESS–SIRT1–Ku70 signaling promoted NHEJ-mediated radioresistance in cervical cancer models
TIMELESS scaffolded SIRT1-mediated Ku70 deacetylation, enhanced NHEJ repair and increased radioresistance in cervical cancer cells and xenografts.
ARIA phase I will test five-fraction MR-guided RT for early glottic cancer
The 20-patient ARIA study will test 5×8.5 Gy MR-guided adaptive RT with gating for cT1–2N0M0 glottic cancer.
Higher LINAC SRS dose rate was linked to longer pain control in trigeminal neuralgia
Treatment failure at one year was 14.4% at 2400 MU/min versus 42.7% at 800 MU/min, with similar facial numbness.
Kidney doses below QUANTEC limits still tracked with chronic kidney disease after para-aortic RT
Seven-year stage 3B CKD rose from 0% below 5 Gy mean kidney dose to 26.4% at ≥10 Gy.