Breast edema appeared after the first fraction in 5-fraction radiotherapy
CBCT detected breast edema in 37.1% during 26 Gy in five fractions, usually immediately after the first treatment.
Tag
Breast
Breast re-irradiation achieved 84.2% five-year recurrence-free survival with 3.9% grade 3 toxicity
After resection of ipsilateral recurrence, five-year locoregional recurrence-free survival was 84.2%, while grade 3 late toxicity was 3.9%.
Moderately hypofractionated regional nodal irradiation had 6.4% three-year lymphedema
With 42.56 Gy in 16 fractions, three-year lymphedema was 6.4%, with no new events through five years.
Aperture-restricted VMAT substantially reduced heart dose during left-sided regional nodal irradiation
Restricting deep VMAT apertures reduced heart and ipsilateral lung exposure across three linacs while maintaining comprehensive breast and nodal coverage.
Dynamic IMRT shortened left-breast DIBH delivery while limiting low-dose exposure
Dynamic tangential IMRT delivered left-breast DIBH 42% faster than VMAT with similar target coverage and lower low-dose normal-tissue exposure.
Persistent internal mammary nodes on MRI identified patients associated with benefit from boost
Internal mammary node boost was associated with better disease-free survival only when MRI showed residual nodal disease after neoadjuvant therapy.
HyperSight CBCT approached simulation-CT dosimetry for offline adaptive breast radiotherapy
HyperSight reduced PTV dose-recalculation deviations versus Halcyon 3.1 while using a lower imaging dose in 12 breast radiotherapy patients.
Neoadjuvant chemotherapy shifted HR+/HER2− breast tumors toward higher genomic radioresistance
RSI increased after neoadjuvant chemotherapy in 23 of 30 matched HR+/HER2− tumors, but implications for adjuvant radiation dose remain unproven.
Modern proton breast radiotherapy offers cardiopulmonary sparing but randomized clinical benefit remains pending
Modern proton techniques reduce cardiopulmonary dose and can control skin exposure, while randomized cardiac and cancer-control endpoints remain pending.
Food insecurity predicted markedly worse survival after comprehensive breast nodal irradiation
Five-year survival was 74.9% versus 90.2% for patients living in food-insecure versus other areas despite similar cancer treatment.
Clinical-genomic models improved prediction of late breast radiotherapy toxicity
Adding SNP data increased arm-lymphedema prediction AUC from 0.78 to 0.93 in the multicenter REQUITE cohort.
Particle therapy suppressed aggressive breast cancer behavior beyond clonogenic cell killing
Protons, helium and carbon ions suppressed migration and invasion that increased after photon irradiation, with helium showing a favorable biological-dosimetric balance.
FES PET changed nodal staging, field design and boost dose in ER-positive breast cancer
In a diagnostically difficult breast cancer case, FES PET identified occult ER-positive nodal disease and materially changed radiotherapy volume and dose.
Patients with documented fatigue were less likely to complete electronic symptom surveys after breast RT
Patients with clinician-documented fatigue had 39% lower odds of completing electronic fatigue assessments, exposing an important limitation of PRO-only monitoring.
ALTJ V35Gy above 50% tripled lymphedema risk after breast radiotherapy
Irradiating more than half of the axillary-lateral thoracic junction to 35 Gy was independently associated with a threefold higher lymphedema risk.