Respiratory gating reduced lung SBRT target volumes and normal-tissue dose
A 30–70% gating window reduced planning target volume by 34% and mean lung dose by 0.75 Gy without compromising coverage.
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sbrt
Cardiac-dose model validated non-cancer death risk in one lung SBRT cohort
The model calibrated well only when non-cancer death was defined consistently; an overall-survival version validated in both external cohorts.
Adaptive MR-guided prostate SBRT showed low toxicity after the early treatment peak
Grade ≥2 urinary toxicity fell from 22% at two weeks to 3% at six months, with almost no clinically significant bowel toxicity.
Protons reduced spinal cord and bowel dose in single-fraction spine SBRT plans
Proton plans preserved 20-Gy target coverage while reducing spinal cord, oesophageal, lung, and bowel dose compared with photon VMAT.
ESTRO defined minimum standards for prostate SBRT implementation
ESTRO recommends prostate SBRT for selected intermediate-risk disease with MRI-based contouring, rigorous quality assurance, and daily image guidance.
Immune-sparing lung SBRT planning reduced lymphocyte loss in a randomized phase II trial
Optimizing dose to blood- and immune-rich structures reduced lymphocyte depletion and prevented grade 3 lymphopenia after early-stage lung SBRT.
Five-fraction prostate SBRT showed low severe toxicity across Austrian centres
Linac-based 40 Gy in five fractions produced low severe toxicity and rapid urinary recovery across seven centres, although follow-up remained short.
SBRT did not reproduce brachytherapy dose escalation in gynecologic cancers
SBRT provided competitive peripheral coverage in some plans but could not consistently reproduce brachytherapy’s central dose escalation after realistic margins were applied.
Prostate reirradiation strategies remain heterogeneous despite encouraging prospective outcomes
Prospective prostate reirradiation studies reported generally acceptable toxicity, but target volumes, dose schedules and organ constraints varied substantially.
Dose reporting mode affected spine SBRT audit results
A national end-to-end audit found acceptable spine stereotactic radiotherapy accuracy but systematic differences between dose-reporting conventions.
Five-fraction prostate and pelvic nodal SBRT showed low late toxicity
After prostate and pelvic nodal SBRT, no grade ≥3 late GU or GI toxicity occurred among 101 patients with high-risk disease.
Cardiac toxicity occurred in 8% after central and ultracentral lung SBRT
Symptomatic grade ≥2 cardiac toxicity occurred in 8% after central or ultracentral lung SBRT, typically developing more than one year after treatment.
Lung SBRT studies use inconsistent definitions of local control
Nearly one-third of lung SBRT studies counted failures beyond the treated tumor as local events, limiting comparison of reported control rates.
Pelvis-inclusive SBRT reduced acute gastrointestinal toxicity in high-risk prostate cancer
Once-weekly prostate-and-pelvis SBRT reduced acute gastrointestinal toxicity versus conventional IMRT without significantly increasing genitourinary toxicity.
Higher CTV minimum dose predicts local control after separation surgery and spine SBRT
Higher postoperative CTV minimum BED10 was associated with lower local failure after separation surgery and spine SBRT.