Proton use reached nearly 40% in recent Children’s Oncology Group radiotherapy trials
Across 27 years of COG trials, IMRT/VMAT replaced 3D photons while proton use expanded to nearly 40% of radiotherapy patients.
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Progesterone exposure was associated with visual deficits in women with meningioma
Unopposed progesterone use was associated with eightfold higher odds of tumor-related visual deficit among women referred for meningioma radiotherapy.
Treatment satisfaction remained 85% at ten years after prostate LDR brachytherapy
At ten years after prostate LDR brachytherapy, 85% of respondents remained satisfied, while bowel quality of life remained independently associated with satisfaction.
Brain metastasis SRS fractionation varied widely across Turkish radiation oncologists
Tumor volume and OAR proximity drove brain metastasis fractionation, while preoperative SRS showed a substantial preference-to-practice gap.
Patients with documented fatigue were less likely to complete electronic symptom surveys after breast RT
Patients with clinician-documented fatigue had 39% lower odds of completing electronic fatigue assessments, exposing an important limitation of PRO-only monitoring.
ALTJ V35Gy above 50% tripled lymphedema risk after breast radiotherapy
Irradiating more than half of the axillary-lateral thoracic junction to 35 Gy was independently associated with a threefold higher lymphedema risk.
OmicsMap improved CT-based distant metastasis prediction across head and neck cancer cohorts
Modeling relationships between CT radiomic features improved distant-metastasis prediction over conventional radiomics across independent head and neck cancer cohorts.
Higher immune-cell radiation dose was associated with worse breast cancer-specific survival
Each 1-Gy increase in estimated immune-cell dose was associated with 66% higher breast cancer mortality after multivariable adjustment.
ASTRO survey maps different workforce pressures across US radiation oncology practice
Administrative burden and staffing concerns were widespread, while reimbursement dominated private-practice concerns and unstable research funding dominated physician-scientist concerns.
SBRT plus dual checkpoint blockade produced 72.7% six-month PFS in oligometastatic HNSCC
Durvalumab, tremelimumab and SBRT produced 72.7% six-month progression-free survival in 33 patients with oligometastatic HNSCC.
Most glioblastoma recurrences clustered within 10 mm of the original GTV
In 201 recurrent glioblastomas, 80% required no more than 10.4 mm expansion to encompass 80% of recurrence volume.
KROG 19-09 reveals major dose variation within intended breast nodal treatment groups
Substantial physician-dependent dose variation meant treatment-group assignment did not consistently reflect the dose actually delivered to regional nodes.
SRT did not improve survival over whole-brain radiotherapy after matching in SCLC
After propensity matching, SRT did not improve survival over WBRT, while adding a boost showed a non-robust intracranial control signal.
Internal mammary node response may reveal occult disease in early breast cancer
Nearly 40% of visible internal mammary nodes regressed after chemotherapy, including 22% in patients without axillary nodal disease.
Radiotherapy was not associated with longer survival in breast cancer leptomeningeal disease
In 232 women with breast cancer leptomeningeal disease, radiotherapy was not associated with longer overall survival, while systemic therapy was.